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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Wang, Bo Akanbi, Olusola Anuoluwapo Harms, Dominik Adesina, Olufisayo Osundare, Folakemi Abiodun Naidoo, Dhamari Deveaux, Isabel Ogundiran, Opeayo Ugochukwu, Uzoma Mba, Nwando Ihekweazu, Chikwe Bock, C.-Thomas |
| Abstract | Background In 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of the hepatitis E virus (HEV) genotypes responsible for the outbreak revealed the predominance of HEV genotypes 1 (HEV-1) and 2 (HEV-2). Molecular data of HEV-2 genomes are limited; therefore we characterized a HEV-2 strain of the outbreak in more detail. Finding The full-length genome sequence of an HEV-2 strain (NG/17–0500) from the outbreak was amplified using newly designed consensus primers. Comparison with other HEV complete genome sequences, including the only HEV-2 strain (Mex-14) with available complete genome sequences and the availability of data of partial HEV-2 sequences from Sub-Saharan Africa, suggests that NG/17–0500 belongs to HEV subtype 2b (HEV-2b). Conclusions We identified a novel HEV-2b strain from Sub-Saharan Africa, which is the second complete HEV-2 sequence to date, whose natural history and epidemiology merit further investigation. |
| Related Links | https://virologyj.biomedcentral.com/counter/pdf/10.1186/s12985-018-1082-8.pdf |
| Ending Page | 6 |
| Page Count | 6 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s12985-018-1082-8 |
| Journal | Virology Journal |
| Issue Number | 1 |
| Volume Number | 15 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2018-10-23 |
| Access Restriction | Open |
| Subject Keyword | Virology Hepatitis E virus HEV genotype 2 HEV subtype 2b Outbreak Nigeria Complete genome |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Infectious Diseases |
| Journal Impact Factor | 4/2023 |
| 5-Year Journal Impact Factor | 3.8/2023 |
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