NDLI: Clinical, molecular, and histological characteristics of severely necrotic and fatal mpox in HIV-infected patients

Content Provider	Springer Nature : BioMed Central
Author	Rajme-López, Sandra Corral-Herrera, Ever A. Tello-Mercado, Andrea C. Tepo-Ponce, Karen M. Pérez-Meléndez, Raúl E. Rosales-Sotomayor, Ángela Figueroa-Ramos, Grecia López-López, Karla Domínguez-Cherit, Judith G. San-Martín-Morante, Oswaldo Saeb-Lima, Marcela Gamboa-Domínguez, Armando Ponce-de-León, Alfredo Crabtree-Ramírez, Brenda Ramos-Cervantes, Pilar Ruíz-Palacios, Guillermo M.
Abstract	Background This case series of 5 patients with severely necrotic mpox highlights the predominantly necrotic nature of lesions seen in cases of severe mpox as shown by skin and lung biopsy, as well as the extensive dissemination of the infection, as shown by polymerase chain reaction (PCR) assessment in different body sites. Case presentations Patients were male, the median age was 37, all lived with HIV (2 previously undiagnosed), the median CD4+ cell count was 106 cells/mm3, and 2/5 were not receiving antiretroviral treatment. The most common complication was soft tissue infection. Skin and lung biopsies showed extensive areas of necrosis. Mpox PCR was positive in various sites, including skin, urine, serum, and cerebrospinal fluid. The initiation of antiretroviral treatment, worsened the disease, like that seen in immune reconstitution syndrome. Three patients died due to multiple organ failure, presumably associated with mpox since coinfections and opportunistic pathogens were ruled out. Conclusions Severely necrotic manifestations of mpox in people living with advanced and untreated HIV are related to adverse outcomes.
Related Links	https://aidsrestherapy.biomedcentral.com/counter/pdf/10.1186/s12981-023-00580-6.pdf
Ending Page	8
Page Count	8
Starting Page	1
File Format	HTM / HTML
ISSN	17426405
DOI	10.1186/s12981-023-00580-6
Journal	AIDS Research and Therapy
Issue Number	1
Volume Number	20
Language	English
Publisher	BioMed Central
Publisher Date	2023-11-27
Access Restriction	Open
Subject Keyword	Infectious Diseases Virology Mpox Severe Disease HIV Histopathology
Content Type	Text
Resource Type	Case study
Subject	Molecular Medicine Virology Pharmacology (medical)
Journal Impact Factor	2.1/2023
5-Year Journal Impact Factor	2.4/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Clinical characteristics and outcome of Penicillium marneffei infection among HIV-infected patients in northern Vietnam

The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer’s disease

Increased mortality after a first myocardial infarction in human immunodeficiency virus-infected patients; a nested cohort study

Tocilizumab in HIV patient with severe COVID-19: case report

Clinical outcomes after IL-6 blockade in patients with COVID-19 and HIV: a case series

Public health response to Mpox: Safeguarding vulnerable Key Populations and People Living with HIV in Zanzibar

The lived experience of HIV-infected patients in the face of a positive diagnosis of the disease: a phenomenological study

Ixekizumab: an alternative for HIV-positive psoriasis patients

Low frequency of genotypic resistance in HIV-1-infected patients failing an atazanavir-containing regimen: a clinical cohort study

Clinical, molecular, and histological characteristics of severely necrotic and fatal mpox in HIV-infected patients

Similar Documents

Clinical characteristics and outcome of Penicillium marneffei infection among HIV-infected patients in northern Vietnam

The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer’s disease

Increased mortality after a first myocardial infarction in human immunodeficiency virus-infected patients; a nested cohort study

Tocilizumab in HIV patient with severe COVID-19: case report

Clinical outcomes after IL-6 blockade in patients with COVID-19 and HIV: a case series

Public health response to Mpox: Safeguarding vulnerable Key Populations and People Living with HIV in Zanzibar

The lived experience of HIV-infected patients in the face of a positive diagnosis of the disease: a phenomenological study

Ixekizumab: an alternative for HIV-positive psoriasis patients

Low frequency of genotypic resistance in HIV-1-infected patients failing an atazanavir-containing regimen: a clinical cohort study

Clinical, molecular, and histological characteristics of severely necrotic and fatal mpox in HIV-infected patients