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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Argente-Escrig, Herminia Bataller, Luis Krstulovic Roa, Claudio Pérez Guillén, Vanesa Perez Garrigues, Herminio Casanova Estruch, Bonaventura |
| Abstract | Background Acquired periodic alternating nystagmus (PAN) is a rare but well-defined syndrome that consists of a horizontal nystagmus that cyclically reverses its direction. PAN can be caused by degenerative, neoplastic, or toxic diseases of the cerebellum and, in a few cases, by subacute cerebellar ataxia of immune origin. Case presentation A 44-year-old man came to our attention because of rapidly progressive gait instability and blurred vision. Clinical examination showed PAN and a mild pancerebellar syndrome. Eye movement recordings disclosed a short cycle PAN with significant slow-phase velocity only in darkness. Under the effect of a γ-aminobutyric acid type B (GABAB) agonist, PAN was not modified. Right after treatment with intravenous immunoglobulin (IVIg) was started, PAN was essentially eliminated. Three months after last dose of IVIg, this nystagmus reappeared. Conclusions IVIg resolved PAN in this patient. This finding may point to an autoimmune mechanism underlying this patient’s nystagmus. This case suggests that the usefulness of IVIg at treating PAN might be worth a consideration in similar clinical settings. |
| Related Links | https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-017-0846-1.pdf |
| Ending Page | 4 |
| Page Count | 4 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17422094 |
| DOI | 10.1186/s12974-017-0846-1 |
| Journal | Journal of Neuroinflammation |
| Issue Number | 1 |
| Volume Number | 14 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2017-03-31 |
| Access Restriction | Open |
| Subject Keyword | Neurosciences Neurology Neurobiology Immunology Nystagmus Oscillopsia Autoimmune disease Gait disorders Ataxia Cerebellum |
| Content Type | Text |
| Resource Type | Case study |
| Subject | Neuroscience Immunology Cellular and Molecular Neuroscience Neurology |
| Journal Impact Factor | 9.3/2023 |
| 5-Year Journal Impact Factor | 9.8/2023 |
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