NDLI: Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage

Content Provider	Springer Nature : BioMed Central
Author	Yuan, Yinglin Cui, Yuanyuan Zhao, Dayue Yuan, Yuan Zhao, Yanshuang Li, Danni Jiang, Xiaomei Zhao, Gaoping
Abstract	The shortage of organs for transplantation emphasizes the urgent need for alternative solutions. Xenotransplantation has emerged as a promising option due to the greater availability of donor organs. However, significant hurdles such as hyperacute rejection and organ ischemia–reperfusion injury pose major challenges, largely orchestrated by the complement system, and activated immune responses. The complement system, a pivotal component of innate immunity, acts as a natural barrier for xenotransplantation. To address the challenges of immune rejection, gene-edited pigs have become a focal point, aiming to shield donor organs from human immune responses and enhance the overall success of xenotransplantation. This comprehensive review aims to illuminate strategies for regulating complement networks to optimize the efficacy of gene-edited pig xenotransplantation. We begin by exploring the impact of the complement system on the effectiveness of xenotransplantation. Subsequently, we delve into the evaluation of key complement regulators specific to gene-edited pigs. To further understand the status of xenotransplantation, we discuss preclinical studies that utilize gene-edited pigs as a viable source of organs. These investigations provide valuable insights into the feasibility and potential success of xenotransplantation, offering a bridge between scientific advancements and clinical application.
Related Links	https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-024-05136-4.pdf
Ending Page	14
Page Count	14
Starting Page	1
File Format	HTM / HTML
ISSN	14795876
DOI	10.1186/s12967-024-05136-4
Journal	Journal of Translational Medicine
Issue Number	1
Volume Number	22
Language	English
Publisher	BioMed Central
Publisher Date	2024-04-02
Access Restriction	Open
Subject Keyword	Biomedicine Medicine Public Health Xenotransplantation Complement systems Genetically modified pigs Clinical trials α-1,3-galactosyltransferase gene-knockout Medicine/Public Health
Content Type	Text
Resource Type	Review
Subject	Biochemistry, Genetics and Molecular Biology Medicine
Journal Impact Factor	6.1/2023
5-Year Journal Impact Factor	6.3/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The anti-nonGal xenoantibody response to α1,3-galactosyltransferase gene knockout pig xenografts

Impact of Thrombocytopenia on Survival of Baboons with Genetically Modified Pig Liver Transplants: Clinical Relevance

Cardiac xenotransplantation

Anti-gal antibodies in α1,3-galactosyltransferase gene-knockout pigs

Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

Genetically Modified Pigs as Organ Donors for Xenotransplantation

Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models?

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein

Comparison of hematologic, biochemical, and coagulation parameters in α1,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate species

Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage

Similar Documents

The anti-nonGal xenoantibody response to α1,3-galactosyltransferase gene knockout pig xenografts

Impact of Thrombocytopenia on Survival of Baboons with Genetically Modified Pig Liver Transplants: Clinical Relevance

Cardiac xenotransplantation

Anti-gal antibodies in α1,3-galactosyltransferase gene-knockout pigs

Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

Genetically Modified Pigs as Organ Donors for Xenotransplantation

Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models?

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein

Comparison of hematologic, biochemical, and coagulation parameters in α1,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate species

Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage