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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Xilifu, Nuerbiya Zhang, Rui Dai, Yongling Maimaiti, Miyeshaer Li, Zhangyan Yang, Ju Zang, Shufei Liu, Jun |
| Abstract | Objective Our aim was to explore the relationship between serum uric acid (UA) levels in early pregnancy and the development of gestational diabetes mellitus (GDM), and to further explore whether there is a causal relationship. Methods 684 pregnant women with GDM and 1162 pregnant women without GDM participated in this study. 311 pregnant women with GDM and 311 matched controls were enrolled in a 1:1 case-control study. We used conditional logistic regression to explore the relationship between UA levels and the risk of developing GDM. The causal relationship between the two was examined by two-sample Mendelian randomization (MR) analysis. Results In the 1:1 matched population, the odds ratio (OR) of developing GDM compared with the extreme tertiles of UA levels was 1.967 (95% confidence interval [CI]: 1.475–2.625; P < 0.001). Restricted cubic spline analyses showed a linear relationship between UA and GDM when UA exceeded 222 µmol/L. GDM and UA levels maintained a statistically significant positive correlation in different stratified regression analyses (P < 0.001). However, no evidence of a causal relationship between uric acid and GDM was found by MR analyses with an OR of 1.06 (95% CI: 0.91–1.25) per unit increase in UA. Conclusion There is a positive correlation between UA levels in early pregnancy and the subsequent risk of developing GDM. However, no genetic evidence was found to support a cause-effect relationship between UA and GDM. |
| Related Links | https://rbej.biomedcentral.com/counter/pdf/10.1186/s12958-024-01278-8.pdf |
| Ending Page | 8 |
| Page Count | 8 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14777827 |
| DOI | 10.1186/s12958-024-01278-8 |
| Journal | Reproductive Biology and Endocrinology |
| Issue Number | 1 |
| Volume Number | 22 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2024-08-27 |
| Access Restriction | Open |
| Subject Keyword | Reproductive Medicine Endocrinology Early pregnancy uric acid (UA) Gestational diabetes mellitus (GDM) Mendelian randomization analysis (MR) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology Obstetrics and Gynecology Developmental Biology Reproductive Medicine |
| Journal Impact Factor | 4.2/2023 |
| 5-Year Journal Impact Factor | 5.3/2023 |
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