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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | An, Yanan Li, Yan Wang, Xueyan Chen, Zhaobin Xu, Hongyue Wu, Lingyu Li, Shulin Wang, Chao Luan, Wenjing Wang, Xuefei Liu, Mingyuan Tang, Xudong Yu, Lu |
| Abstract | Background An increasing number of studies have shown that obesity is the key etiological agent of cardiovascular diseases, nonalcoholic fatty liver disease, type 2 diabetes and several kinds of cancer and that gut microbiota change was one of the reasons suffering from obesity. At present, the gut microbiota has gained increased attention as a potential energy metabolism organ. Our recent study reported that cordycepin, a major bioactive component separated from Cordyceps militaris, prevented body weight gain in mice fed a high-fat diet directly acting to adipocytes, however, the effect of cordycepin regulating gut microbiota keeps unknown. Methods In this research, we synthesized cordycepin (3-deoxyadenosine) by chemical methods and verified that cordycepin reduces body weight gain and fat accumulation around the epididymis and the kidneys of rats fed a high-fat diet. Furthermore, we used high-throughput sequencing on a MiSeq Illumina platform to test the species of intestinal bacteria in high-fat-diet-induced obese rats. Results We found that cordycepin modifies the relative abundance of intestinal bacteria in high-fat-diet-induced obese rats. However, cordycepin did not alter the variety of bacteria in the intestine. Cordycepin treatment dramatically reversed the relative abundance of two dominant bacterial phyla (Bacteroidetes and Firmicutes) in the high-fat-diet-induced obese rats, resulting in abundance similar to that of the chow diet group. Conclusion Our study suggests that cordycepin can reduce body weight and microbiome done by cordycepin seems be a result among its mechanisms of obesity reduction. |
| Related Links | https://lipidworld.biomedcentral.com/counter/pdf/10.1186/s12944-018-0910-6.pdf |
| Ending Page | 10 |
| Page Count | 10 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s12944-018-0910-6 |
| Journal | Lipids in Health and Disease |
| Issue Number | 1 |
| Volume Number | 17 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2018-12-06 |
| Access Restriction | Open |
| Subject Keyword | Lipidology Medical Biochemistry Clinical Nutrition Cordycepin Gut microbiota Obesity Body weight Fat |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology Clinical Biochemistry Endocrinology, Diabetes and Metabolism Biochemistry (medical) |
| Journal Impact Factor | 3.9/2023 |
| 5-Year Journal Impact Factor | 4.3/2023 |
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