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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Chi, Chen Teliewubai, Jiadela Lu, Yu-Yan Fan, Xi-Min Yu, Shi-Kai Xiong, Jing Zhou, Yi-Wu Ji, Hong-Wei Zhang, Yi Xu, Ya-wei |
| Abstract | Background Recommendations of non-HDL amplification varied from different guidelines. We aim to test the relationships between various lipid parameters and target organ damage (TOD) including aortic stiffness, peripheral arterial disease and chronic kidney disease in a community-based elderly cohort. Methods 1599 (aged 71.4 ± 6.1 years) participants were recruited. Eight lipid parameters, including total cholesterol (TC), triglycerides (TG), LDL-C, HDL-C, non-HDL-C, TC/HDL ratio, TG/HDL ratio and LDL/HDL ratio, together with other plasma biomarkers like creatinine were measured. Pulse wave velocity (PWV) was measured by the SphygmoCor device, and ankle-brachial index (ABI) was assessed by Omron VP-1000 device. Results Four individual lipid parameters (TC, TG, LDL-C and HDL-C) significantly correlated with most, but not all, TOD indices. Meanwhile, 4 combined lipid parameters, namely non-HDL-C, TC/HDL, TG/HDL and LCL/HDL, significantly correlated with all TOD (P ≤ 0.033). In multiple linear regression analyses, 4 combined lipid parameters also significantly associated with TOD (P ≤ 0.027), while none of individual lipid parameters significantly associated with all TOD indices. In multiple logistic regression analyses, only non-HDLC and TC/HDL significantly associated with TOD (P ≤ 0.039), and other lipid parameters did not significantly associate with TOD. Conclusion In an elderly community sample, non-HDLC and TC/HDLC were better associated with TOD than other lipid parameters. This finding should be considered in future clinical lipid-lowing therapy. Trial registration This trial was retrospectively registered in ClinicalTrials.gov (No. NCT02368938 , registered on 15 Feb 2015). |
| Related Links | https://lipidworld.biomedcentral.com/counter/pdf/10.1186/s12944-018-0800-y.pdf |
| Ending Page | 8 |
| Page Count | 8 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s12944-018-0800-y |
| Journal | Lipids in Health and Disease |
| Issue Number | 1 |
| Volume Number | 17 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2018-08-25 |
| Access Restriction | Open |
| Subject Keyword | Lipidology Medical Biochemistry Clinical Nutrition Target organ damage Lipid Lipoprotein Cholesterol Primary prevention |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology Clinical Biochemistry Endocrinology, Diabetes and Metabolism Biochemistry (medical) |
| Journal Impact Factor | 3.9/2023 |
| 5-Year Journal Impact Factor | 4.3/2023 |
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