NDLI: Correlation between small dense low-density lipoprotein cholesterol and carotid artery intima-media thickness in a healthy Chinese population

Content Provider	Springer Nature : BioMed Central
Author	Shen, Hao Xu, Li Lu, Jingfen Hao, Tianbo Ma, Chunfang Yang, Honglin Lu, Zhaoyang Gu, Yongchun Zhu, Tonghua Shen, Guorong
Abstract	Background Small dense low-density lipoprotein cholesterol (sdLDL-C) concentration was useful in the assessment of the presence of cardiovascular diseases (CVD) and its severity. We examined whether SdLDL-C is more closely associated with carotid artery intima-media thickness (CA-IMT), a surrogate measure of atherosclerosis, than LDL-C and traditional CVD risk factors in Chinese healthy subjects. Methods We measured CA-IMT, blood pressure (BP), sdLDL-C, glucose metabolism and lipid in 183 native Chinese healthy subjects. CA-IMT was assessed by ultrasonography, and sdLDL-C concentrations were measured by a homogenous assay. Pearson's correlation coefficient analyses and Multiple regression analyses were used to examine the relationships between CA-IMT values and other clinical variables. Results The sdLDL-C level was significantly higher in males than in females (p <0.05) and there was an age effect on sdLDL-C (p <0.05). When the effects of age, gender and other traditional CVD risk factors were adjusted using multiple regression analysis. CA-IMT remained significantly associated with sdLDL-C(β = 0.437, p <0.001). Conclusions There are gender and age differences in sdLDL-C levels among a healthy Chinese population. Moreover, we found adjusted traditional CVD risk factors such as higher age, male sex, and other traditional CVD risk factors, the association between CA-IMT and SdLDL-C remained significant. sdLDL-C is may be a useful predictor in the assessment of CA-IMT in Chinese population.
Related Links	https://lipidworld.biomedcentral.com/counter/pdf/10.1186/s12944-015-0143-x.pdf
Ending Page	6
Page Count	6
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s12944-015-0143-x
Journal	Lipids in Health and Disease
Issue Number	1
Volume Number	14
Language	English
Publisher	BioMed Central
Publisher Date	2015-10-29
Access Restriction	Open
Subject Keyword	Lipidology Medical Biochemistry Clinical Nutrition Small dense low-density lipoprotein cholesterol Carotid artery intima-media thickness Chinese subjects
Content Type	Text
Resource Type	Article
Subject	Endocrinology Clinical Biochemistry Endocrinology, Diabetes and Metabolism Biochemistry (medical)
Journal Impact Factor	3.9/2023
5-Year Journal Impact Factor	4.3/2023

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