NDLI: Amoxillin- and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues

Content Provider	Springer Nature : BioMed Central
Author	Rotimi, Solomon O Ojo, David A Talabi, Olusola A Ugbaja, Regina N Balogun, Elizabeth A Ademuyiwa, Oladipo
Abstract	Background To investigate whether amoxillin and pefloxacin perturb lipid metabolism. Methods Rats were treated with therapeutic doses of each antibiotic for 5 and 10 days respectively. Twenty four hours after the last antibiotic treatment and 5 days after antibiotic withdrawal, blood and other tissues (liver, kidney, brain, heart and spleen) were removed from the animals after an overnight fast and analysed for their lipid contents. Results Both antibiotics produced various degrees of compartment-specific dyslipidemia in the animals. While plasma and erythrocyte dyslipidemia was characterised by up-regulation of the concentrations of the major lipids (cholesterol, triglycerides, phospholipids and free fatty acids), hepatic and renal dyslipidemia was characterised by cholesterogenesis and phospholipidosis. Splenic dyslipidemia was characterised by cholesterogenesis and decreased phospholipid levels. Cardiac and brain cholesterol contents were not affected by the antibiotics. A transient phospholipidosis was observed in the brain whereas cardiac phospholipids decreased significantly. Lipoprotein abnormalities were reflected as down-regulation of HDL cholesterol. Furthermore, the two antibiotics increased the activity of hepatic HMG-CoA reductase. Although erythrocyte phospholipidosis was resolved 5 days after withdrawing the antibiotics, dyslipidemia observed in other compartments was still not reversible. Conclusion Our findings suggest that induction of cholesterogenesis and phospholipidosis might represent additional adverse effects of amoxillin and pefloxacin.
Related Links	https://lipidworld.biomedcentral.com/counter/pdf/10.1186/s12944-015-0011-8.pdf
Ending Page	17
Page Count	17
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s12944-015-0011-8
Journal	Lipids in Health and Disease
Issue Number	1
Volume Number	14
Language	English
Publisher	BioMed Central
Publisher Date	2015-02-21
Access Restriction	Open
Subject Keyword	Lipidology Medical Biochemistry Clinical Nutrition Amoxillin Pefloxacin Dyslipidemia Cholesterogenesis Phospholipidosis
Content Type	Text
Resource Type	Article
Subject	Endocrinology Clinical Biochemistry Endocrinology, Diabetes and Metabolism Biochemistry (medical)
Journal Impact Factor	3.9/2023
5-Year Journal Impact Factor	4.3/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Tissue dyslipidemia in salmonella-infected rats treated with amoxillin and pefloxacin

Pharmacogenomic analysis of retinoic-acid induced dyslipidemia in congenic rat model

Atorvastatin protects endothelium by decreasing asymmetric dimethylarginine in dyslipidemia rats

Association of NCOA3 polymorphisms with Dyslipidemia in the Chinese Han population

Positive correlation between snoring and dyslipidemia in adults: results from NHANES

Prevalence of dyslipidemia associated with complications in diabetic patients: a nationwide study in Thailand

Persistent dyslipidemia increases the longitudinal changes in telomere length

Treatment of dyslipidemia in patients with type 2 diabetes

Serum lipids and associated factors of dyslipidemia in the adult population in Shenzhen

Amoxillin- and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues

Similar Documents

Tissue dyslipidemia in salmonella-infected rats treated with amoxillin and pefloxacin

Pharmacogenomic analysis of retinoic-acid induced dyslipidemia in congenic rat model

Atorvastatin protects endothelium by decreasing asymmetric dimethylarginine in dyslipidemia rats

Association of NCOA3 polymorphisms with Dyslipidemia in the Chinese Han population

Positive correlation between snoring and dyslipidemia in adults: results from NHANES

Prevalence of dyslipidemia associated with complications in diabetic patients: a nationwide study in Thailand

Persistent dyslipidemia increases the longitudinal changes in telomere length

Treatment of dyslipidemia in patients with type 2 diabetes

Serum lipids and associated factors of dyslipidemia in the adult population in Shenzhen

Amoxillin- and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues