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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Karami Fath, Mohsen Azami, Jalil Masoudi, Alireza Mosaddeghi Heris, Reza Rahmani, Elnaz Alavi, Fatemeh Alagheband Bahrami, Armina Payandeh, Zahra Khalesi, Bahman Dadkhah, Masoomeh Pourzardosht, Navid Tarhriz, Vahideh |
| Abstract | Glioblastoma belongs to the most aggressive type of cancer with a low survival rate that is characterized by the ability in forming a highly immunosuppressive tumor microenvironment. Intercellular communication are created via exosomes in the tumor microenvironment through the transport of various biomolecules. They are primarily involved in tumor growth, differentiation, metastasis, and chemotherapy or radiation resistance. Recently several studies have highlighted the critical role of tumor-derived exosomes against immune cells. According to the structural and functional properties, exosomes could be essential instruments to gain a better molecular mechanism for tumor understanding. Additionally, they are qualified as diagnostic/prognostic markers and therapeutic tools for specific targeting of invasive tumor cells such as glioblastomas. Due to the strong dependency of exosome features on the original cells and their developmental status, it is essential to review their critical modulating molecules, clinical relevance to glioma, and associated signaling pathways. This review is a non-clinical study, as the possible role of exosomes and exosomal microRNAs in glioma cancer are reported. In addition, their content to overcome cancer resistance and their potential as diagnostic biomarkers are analyzed. |
| Related Links | https://cancerci.biomedcentral.com/counter/pdf/10.1186/s12935-022-02642-7.pdf |
| Ending Page | 21 |
| Page Count | 21 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14752867 |
| DOI | 10.1186/s12935-022-02642-7 |
| Journal | Cancer Cell International |
| Issue Number | 1 |
| Volume Number | 22 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2022-08-21 |
| Access Restriction | Open |
| Subject Keyword | Cancer Research Cell Biology Glioblastoma multiforme Exosome Immunotherapy MicroRNA Biomarkers |
| Content Type | Text |
| Resource Type | Review |
| Subject | Cancer Research Genetics Oncology |
| Journal Impact Factor | 5.3/2023 |
| 5-Year Journal Impact Factor | 5/2023 |
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