NDLI: How metformin affects various malignancies by means of microRNAs: a brief review

Content Provider	Springer Nature : BioMed Central
Author	Alimoradi, Nahid Firouzabadi, Negar Fatehi, Reihaneh
Abstract	Metformin known as the first-line orally prescribed drug for lowering blood glucose in type II diabetes (T2DM) has recently found various therapeutic applications including in cancer. Metformin has been studied for its influences in prevention and treatment of cancer through multiple mechanisms such as microRNA (miR) regulation. Alteration in the expression of miRs by metformin may play an important role in the treatment of various cancers. MiRs are single-stranded RNAs that are involved in gene regulation. By binding to the 3′UTR of target mRNAs, miRs influence protein levels. Irregularities in the expression of miRs that control the expression of oncogenes and tumor suppressor genes are associated with the onset and progression of cancer. Metformin may possess an effect on tumor prevention and progression by modifying miR expression and downstream pathways. Here, we summarize the effect of metformin on different types of cancer by regulating the expression of various miRs and the associated downstream molecules.
Related Links	https://cancerci.biomedcentral.com/counter/pdf/10.1186/s12935-021-01921-z.pdf
Ending Page	13
Page Count	13
Starting Page	1
File Format	HTM / HTML
ISSN	14752867
DOI	10.1186/s12935-021-01921-z
Journal	Cancer Cell International
Issue Number	1
Volume Number	21
Language	English
Publisher	BioMed Central
Publisher Date	2021-04-13
Access Restriction	Open
Subject Keyword	Cancer Research Cell Biology Metformin MicroRNAs Cancer AMPK Biomarker Mechanism of action
Content Type	Text
Resource Type	Review
Subject	Cancer Research Genetics Oncology
Journal Impact Factor	5.3/2023
5-Year Journal Impact Factor	5/2023

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