NDLI: Circular RNA CDR1as promotes tumor progression by regulating miR-432-5p/E2F3 axis in pancreatic cancer

Content Provider	Springer Nature : BioMed Central
Author	Xiong, Xingcheng Feng, Jiarui Yang, Xiao Li, Hanjun Shi, Qiao Tao, Jing Chang, Jian
Abstract	Background Pancreatic cancer (PC), characterized with high growth rate and metastatic rate. It’s urgently necessary to explore new mechanism of PC. Circular RNA/miRNA/mRNA network was widely reported to participate in the cancer progression. Methods In this research, circular RNA CDR1as (circCDR1as) was identified by microarray analysis and detected in pancreatic cancer (PC) tissues and cells. Transwell, colony-forming assay, nude mouse tumorigenicity assay were used to determine the function of circCDR1as in PC. Western blot, dual luciferase reporting test were applied to investigate the mechanism. Results We found that circCDR1as was highly expressed in PC tissues. The levels of circCDR1as in PC tissues and cells were higher than those in controls. CircCDR1as promoted the migration, invasion and proliferation of PC cells in vitro and tumor growth in vivo via mediating E2F3 expression by sponging miR-432-5p. Conclusions In conclusion, circCDR1as could promote the development of PC and might be a novel diagnostic target for PC.
Related Links	https://cancerci.biomedcentral.com/counter/pdf/10.1186/s12935-021-01812-3.pdf
Ending Page	10
Page Count	10
Starting Page	1
File Format	HTM / HTML
ISSN	14752867
DOI	10.1186/s12935-021-01812-3
Journal	Cancer Cell International
Issue Number	1
Volume Number	21
Language	English
Publisher	BioMed Central
Publisher Date	2021-02-16
Access Restriction	Open
Subject Keyword	Cancer Research Cell Biology Pancreatic cancer Circular RNA/miRNA/mRNA Tumor progression Early diagnose
Content Type	Text
Resource Type	Article
Subject	Cancer Research Genetics Oncology
Journal Impact Factor	5.3/2023
5-Year Journal Impact Factor	5/2023

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