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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Pourhanifeh, Mohammad Hossein Mohammadi, Rezvan Noruzi, Somaye Hosseini, Seyede Atefe Fanoudi, Sahar Mohamadi, Yousef Hashemzehi, Milad Asemi, Zatollah Mirzaei, Hamid Reza Salarinia, Reza Mirzaei, Hamed |
| Abstract | Fibromodulin (FMOD) is known as one of very important extracellular matrix small leucine-rich proteoglycans. This small leucine-rich proteoglycan has critical roles in the extracellular matrix organization and necessary for repairing of tissue in many organs. Given that the major task of FMOD is the modulation of collagen fibrillogenesis. However, recently observed that FMOD plays very important roles in the modulation of a variety of pivotal biological processes including angiogenesis, regulation of TGF-β activity, and differentiation of human fibroblasts into pluripotent cells, inflammatory mechanisms, apoptosis and metastatic related phenotypes. Besides these roles, FMOD has been considered as a new tumor-related antigen in some malignancies such as lymphoma, leukemia, and leiomyoma. Taken together, these findings proposed that FMOD could be introduced as diagnostic and therapeutic biomarkers in treatment of various cancers. Herein, for first time, we highlighted the various roles of FMOD in the cancerous conditions. Moreover, we summarized the diagnostic and therapeutic applications of FMOD in cancer therapy. |
| Related Links | https://cancerci.biomedcentral.com/counter/pdf/10.1186/s12935-019-0870-6.pdf |
| Ending Page | 9 |
| Page Count | 9 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14752867 |
| DOI | 10.1186/s12935-019-0870-6 |
| Journal | Cancer Cell International |
| Issue Number | 1 |
| Volume Number | 19 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2019-06-10 |
| Access Restriction | Open |
| Subject Keyword | Cancer Research Cell Biology Fibromodulin Diagnosis Therapy Cancer |
| Content Type | Text |
| Resource Type | Review |
| Subject | Cancer Research Genetics Oncology |
| Journal Impact Factor | 5.3/2023 |
| 5-Year Journal Impact Factor | 5/2023 |
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