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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Zhou, Ke Ou, Qin Wang, Geng Zhang, Wenqi Hao, Yin Li, Wenfang |
| Abstract | Background To investigate the expression and significance of long noncoding RNA NORAD (lncRNA-NORAD) in breast cancer. Methods Q-PCR was adopted to detect the mRNA expression of lncRNA-NORAD in breast cancer and adjacent tissues, survival analysis to compare the low-expression groups with the Kaplan–Meier method. Knockout of lncRNA-NORAD was adopted to observe the effects on the cell proliferation, migration and invasion of breast cancer in vitro and in vivo. The TGF-β/RUNX2 signaling pathway was observed by Western blot after the knockout of lncRNA-NORAD. Results Increased expression of lncRNA-NORAD in breast cancer tissues promotes proliferation, invasion and migration of breast cancer cells and correlated with worse prognosis. LncRNA-NORAD activated TGF-β/RUNX2 signaling pathway in breast cancer cells. Conclusions These results strongly suggested that lncRNA-NORAD might play an important role in breast cancer progression and potentially be a new therapeutic target. |
| Related Links | https://cancerci.biomedcentral.com/counter/pdf/10.1186/s12935-019-0781-6.pdf |
| Ending Page | 7 |
| Page Count | 7 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14752867 |
| DOI | 10.1186/s12935-019-0781-6 |
| Journal | Cancer Cell International |
| Issue Number | 1 |
| Volume Number | 19 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2019-03-20 |
| Access Restriction | Open |
| Subject Keyword | Cancer Research Cell Biology Breast cancer LncRNA-NORAD TGF-β |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Genetics Oncology |
| Journal Impact Factor | 5.3/2023 |
| 5-Year Journal Impact Factor | 5/2023 |
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