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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Lee, Jong-Young Ryu, Seungho Lee, Sung Ho Kim, Byung Jin Kim, Bum-Soo Kang, Jin-Ho Cheong, Eun Sun Kim, Jang-Young Park, Jeong Bae Sung, Ki-Chul |
| Abstract | Background Few studies have investigated the association between coronary artery calcium (CAC) progression and arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). We examined the influence of the severity of baseline baPWV on CAC progression in a large prospective cohort. Methods A total of 1600 subjects who voluntarily participated in a comprehensive health-screening program between March 2010 and December 2013 and had baseline baPWV as well as CAC on baseline and serial follow-up computed tomography performed approximately 2.7 ± 0.5 years apart were enrolled in the study. Results A total of 1124 subjects were included in the analysis (1067 men; mean age, 43.6 ± 5.1 years). An increased CAC score was found in 318 subjects (28.3 %) during the follow-up period. Baseline higher baPWV was significantly correlated with CAC progression, especially in subjects with third- and fourth-quartile values (adjusted odds ratio [OR] 2.04; 95 % confidence interval [CI] 1.33–3.15 and OR 2.14; 95 % CI 1.34–3.41, respectively) compared with the lowest-quartile values (P for trend <0.001). A similar effect was observed in diabetic subjects. Among the 835 subjects with a baseline CAC score = 0, progression to CAC score >0 was associated with male sex, diabetes, and higher baPWV. However, among the 289 individuals with a baseline CAC score >0, only the presence of CAC itself was predictive of CAC progression. Conclusions Higher arterial stiffness measured by baPWV could be significantly associated with CAC progression. |
| Related Links | https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-015-0311-3.pdf |
| Ending Page | 9 |
| Page Count | 9 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14752840 |
| DOI | 10.1186/s12933-015-0311-3 |
| Journal | Cardiovascular Diabetology |
| Issue Number | 1 |
| Volume Number | 14 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2015-11-04 |
| Access Restriction | Open |
| Subject Keyword | Diabetes Angiology Cardiology Arterial stiffness baPWV Cardiometabolic risk factors Cardiovascular disease (CVD) Coronary arterial calcification |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine Internal Medicine Endocrinology, Diabetes and Metabolism |
| Journal Impact Factor | 8.5/2023 |
| 5-Year Journal Impact Factor | 8.9/2023 |
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