NDLI: Skeletal muscle insulin resistance in salt-sensitive hypertension: role of angiotensin II activation of NFκB

Content Provider	Springer Nature : BioMed Central
Author	Zhou, Ming-Sheng Liu, Chang Tian, Runxia Nishiyama, Akira Raij, Leopoldo
Abstract	Background We have previously shown that in hypertensive Dahl salt-sensitive (DS) rats, impaired endothelium-dependent relaxation to acetylcholine and to insulin is mechanistically linked to up-regulation of angiotensin (Ang) II actions and the production of reactive oxygen species (ROS) and to activation of the proinflammatory transcription factor (NF)κB. Here we investigated whether Ang II activation of NFκB contributed to insulin resistance in the skeletal muscle of this animal model. Methods DS rats were fed either a normal (NS, 0.5% NaCl) or high (HS, 4% NaCl) salt diet for 6 weeks. In addition, 3 separate groups of HS rats were given angiotensin receptor 1 blocker candesartan (ARB, 10 mg/kg/day in drinking water), antioxidant tempol (1 mmol/L in drinking water) or NFκB inhibitor PDTC (150 mg/kg in drinking water). Results DS rats manifested an increase in soleus muscle Ang II content, ROS production and phosopho-IκBα/IκBα ratio, ARB or tempol reduced ROS and phospho-IκBα/IκBα ratio. Hypertensive DS rats also manifested a reduction in glucose infusion rate, impaired insulin-induced Akt phosphorylation and Glut-4 translocation in the soleus muscle, which were prevented with treatment of either ARB, tempol, or PDTC. Data from the rat diabetes signaling pathway PCR array showed that 8 genes among 84 target genes were altered in the muscle of hypertensive rats with the increase in gene expression of ACE1 and 5 proinflammatory genes, and decrease of 2 glucose metabolic genes. Incubation of the muscle with NFκB SN50 (a specific peptide inhibitor of NFκB) ex vivo reversed changes in hypertension-induced gene expression. Conclusion The current findings strongly suggest that the activation of NFκB inflammatory pathway by Ang II play a critical role in skeletal muscle insulin resistance in salt-sensitive hypertension.
Related Links	https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-015-0211-6.pdf
Ending Page	9
Page Count	9
Starting Page	1
File Format	HTM / HTML
ISSN	14752840
DOI	10.1186/s12933-015-0211-6
Journal	Cardiovascular Diabetology
Issue Number	1
Volume Number	14
Language	English
Publisher	BioMed Central
Publisher Date	2015-05-01
Access Restriction	Open
Subject Keyword	Diabetes Angiology Cardiology Angiotensin II Hypertension Insulin resistance NFκB Skeletal muscle
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Internal Medicine Endocrinology, Diabetes and Metabolism
Journal Impact Factor	8.5/2023
5-Year Journal Impact Factor	8.9/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Skeletal muscle insulin resistance in salt-sensitive hypertension: role of angiotensin II activation of NFκB

Genetic and dietary salt contributors to insulin resistance in Dahl salt-sensitive (S) rats

Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats

The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats

Uteroplacental insufficiency down regulates insulin receptor and affects expression of key enzymes of long-chain fatty acid (LCFA) metabolism in skeletal muscle at birth

Genetic and dietary salt contributors to insulin resistance in Dahl salt-sensitive (S) rats

Association between insulin resistance and the development of cardiovascular disease

Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats

DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure

Skeletal muscle insulin resistance in salt-sensitive hypertension: role of angiotensin II activation of NFκB

Similar Documents

Skeletal muscle insulin resistance in salt-sensitive hypertension: role of angiotensin II activation of NFκB

Genetic and dietary salt contributors to insulin resistance in Dahl salt-sensitive (S) rats

Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats

The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats

Uteroplacental insufficiency down regulates insulin receptor and affects expression of key enzymes of long-chain fatty acid (LCFA) metabolism in skeletal muscle at birth

Genetic and dietary salt contributors to insulin resistance in Dahl salt-sensitive (S) rats

Association between insulin resistance and the development of cardiovascular disease

Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats

DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure

Skeletal muscle insulin resistance in salt-sensitive hypertension: role of angiotensin II activation of NFκB