NDLI: The association between basal metabolic rate and osteoarthritis: a Mendelian randomization study

Content Provider	Springer Nature : BioMed Central
Author	Zhou, Jingyu Wei, Peng Yi, Feng Xiong, Shilang Liu, Min Xi, Hanrui Ouyang, Min Liu, Yayun Li, Jingtang Xiong, Long
Abstract	Background The role of the basal metabolic rate (BMR) in osteoarthritis (OA) remains unclear, as previous retrospective studies have produced inconsistent results. Therefore, we performed a Mendelian randomization (MR) study to systematically investigate the causal relationship between the BMR and OA. Methods Single-nucleotide polymorphism (SNP) data related to BMR and OA were collected in a genome-wide association study. Using OA as the outcome variable and BMR as the exposure factor, SNPs with strong correlation with the BMR as the tool variable were screened. The correlation between the BMR and OA risk was evaluated using the inverse-variance weighted method, and heterogeneity and pleiotropy were evaluated using a sensitivity analysis. Results There was a potential causal relationship between the BMR and OA risk (odds ratio [OR], 1.014; 95% confidence interval [CI], 1.008–1.020; P = 2.29e − 6). A causal relationship was also revealed between the BMR and knee OA (OR, 1.876; 95% CI, 1.677–2.098; P = 2.98e − 28) and hip OA (OR, 1.475; 95% CI, 1.290–1.686; P = 1.26e − 8). Sensitivity analysis confirmed the robustness of these results. Conclusion Here, we identified a latent causal relationship between the BMR and the risk of OA. These results suggest that the risk of OA in the hip or knee joint may be reduced by controlling the BMR.
Related Links	https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/s12920-023-01704-7.pdf
Ending Page	9
Page Count	9
Starting Page	1
File Format	HTM / HTML
ISSN	17558794
DOI	10.1186/s12920-023-01704-7
Journal	BMC Medical Genomics
Issue Number	1
Volume Number	16
Language	English
Publisher	BioMed Central
Publisher Date	2023-10-24
Access Restriction	Open
Subject Keyword	Human Genetics Microarrays Gene Expression Basal metabolic rate Hip osteoarthritis Knee osteoarthritis Genome-wide association study Mendelian randomization
Content Type	Text
Resource Type	Article
Subject	Genetics (clinical) Genetics
Journal Impact Factor	2.1/2023
5-Year Journal Impact Factor	2.5/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mendelian randomization study confirms causal relationship between myopia and vitreous disorders

Association between circulating fatty acid metabolites and asthma risk: a two-sample bidirectional Mendelian randomization study

Causal association of epigenetic aging and osteoporosis: a bidirectional Mendelian randomization study

Effect of basal metabolic rate on osteoporosis: A Mendelian randomization study

Association between venous thromboembolism and atrial fibrillation: a Mendelian randomization study

Genetic association between interleukin-17 and susceptibility to rheumatoid arthritis

Mendelian randomization indicates that atopic dermatitis contributes to the occurrence of diabetes

Exploring genes for immunoglobulin A nephropathy: a summary data-based mendelian randomization and FUMA analysis

Integrative analyses of mendelian randomization and bioinformatics reveal casual relationship and genetic links between COVID-19 and knee osteoarthritis

The association between basal metabolic rate and osteoarthritis: a Mendelian randomization study

Similar Documents

Mendelian randomization study confirms causal relationship between myopia and vitreous disorders

Association between circulating fatty acid metabolites and asthma risk: a two-sample bidirectional Mendelian randomization study

Causal association of epigenetic aging and osteoporosis: a bidirectional Mendelian randomization study

Effect of basal metabolic rate on osteoporosis: A Mendelian randomization study

Association between venous thromboembolism and atrial fibrillation: a Mendelian randomization study

Genetic association between interleukin-17 and susceptibility to rheumatoid arthritis

Mendelian randomization indicates that atopic dermatitis contributes to the occurrence of diabetes

Exploring genes for immunoglobulin A nephropathy: a summary data-based mendelian randomization and FUMA analysis

Integrative analyses of mendelian randomization and bioinformatics reveal casual relationship and genetic links between COVID-19 and knee osteoarthritis

The association between basal metabolic rate and osteoarthritis: a Mendelian randomization study