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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Zhao, Xiaoyu Xiao, Jiechuan Yun, Yuan Bo, Chunjie Gao, Yuxin Song, Lishuang Bai, Chunling Wei, Zhuying Zhang, Li Yang, Lei Su, Guanghua Li, Guangpeng |
| Abstract | Background Long breeding cycle, long calving intervals and typical single calves limit the potential for improving their economic benefits. Ensuring the reproductive performance and efficiency of cows are crucial to increasing their economic value. Factors affecting the reproductive performance of cows include breed, pre-pregnancy maternal preparation, nutrition during pregnancy, and perinatal management. The gene editing of MSTN gene can improve the development of skeletal muscles and provide a new way for the promotion of existing beef cattle breeds. However, little has been reported about the reproductive performance and pregnancy state of MSTN gene-edited animals. In order to evaluate the reproductive safety and physiological changes during pregnancy of MSTN gene-edited cows, this study compared the sizes of reproductive organs, reproductive hormones, blood metabolic indicators, and metabolomic profiles at different stages of pregnancy, including period to be insemination, first trimester, second trimester, and late third trimester in MSTN gene-edited Luxi cattle (MT) and non-edited Luxi cattle (WT). Results The results showed no significant differences in ovary and uterus sizes between MT and WT cows. However, MT cattle exhibited a larger pelvic area and higher calf birth weight. Compared to WT cattle, MT cattle showed enhanced glucose metabolism, reduced lipid synthesis, increased protein synthesis and absorption capacity, and decreased tryptophan synthesis at different stages of pregnancy. The hormone levels showed decreased E2 and increased P4 in MT cattle. Conclusion The study demonstrates that MSTN gene editing has no significant impact on the reproductive safety of dairy cows and provides a deeper understanding of the feasibility of MSTN mutations for beef cattle breeding. |
| Related Links | https://bmcvetres.biomedcentral.com/counter/pdf/10.1186/s12917-025-04742-8.pdf |
| Ending Page | 15 |
| Page Count | 15 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17466148 |
| DOI | 10.1186/s12917-025-04742-8 |
| Journal | BMC Veterinary Research |
| Issue Number | 1 |
| Volume Number | 21 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2025-04-17 |
| Access Restriction | Open |
| Subject Keyword | Veterinary Medicine Veterinary Science Zoology Transgenics Myostatin Gene editing Luxi Beef Cattle Reproductive performance Hematological and biochemical physiology Progesterone Metabolome Veterinary Medicine/Veterinary Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Veterinary Medicine |
| Journal Impact Factor | 2.3/2023 |
| 5-Year Journal Impact Factor | 2.6/2023 |
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