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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Zangueu, Calvin Bogning Olounlade, Abiodoun Pascal Ossokomack, Marlyse Djouatsa, Yolande Noelle Nangue Alowanou, Goue Géorcelin Azebaze, Anatole Guy Blaise Llorent-Martínez, Eulogio José de Córdova, Maria Luisa Fernández Dongmo, Alain Bertrand Hounzangbe-Adote, Mawulé Sylvie |
| Abstract | Background Maytenus senegalensis is a common shrub which is scattered in tropical Africa. Different parts of this plant have been reported to be useful in traditional medicine against gastrointestinal disorders and intestinal worms. This study evaluated the anthelmintic activity of the aqueous stem bark extract of M. senegalensis using egg hatch assay (EHA), larval migration inhibition assay (LMIA) and adult worms’ motility inhibition assay (AMIA). Results On EHA, the extract concentrations tested resulted in a significant (p < 0.01) inhibition of egg hatching in concentration-dependent manner and ranged between 31.86% at 75 μg.mL− 1 to 54.92% at 2400 μg.mL− 1 after a 48 h post-exposure with eggs. For the LMI assays, the aqueous extract of M. senegalensis showed a significant (p < 0.05) inhibition of larval migration in a concentration-dependent manner. The highest concentration used (2400 μg.mL− 1) showed a 37.77% inhibition. The use of polyvinyl polypyrrolidone (PVPP) indicated that tannins and flavonoids were partly involved in the effect since the larval migration was inhibited by 15.5%, but other biochemical compounds were also implicated. On AMIA, M. senegalensis was associated with a reduced worm motility after a 24 h post exposure compared to phosphate buffered saline as control (p < 0.05). By this time 66.66% of the worms’ were found immotile or dead in the wells containing plant extract at 2400 μg.mL− 1. The Phytochemical analysis of aqueous extract of M. senegalensis by HPLC-ESI-MSn detected the presence of proanthocyanidins (20%) and flavonoids (> 50%). Conclusions These in vitro results suggest the presence of some anthelmintic properties in M. senegalensis extract, which is traditionally used by small farmers in west and central Africa. These effects may be due to the flavonoids and proanthocyanidins present in the extract and need to be studied under in vivo conditions. |
| Related Links | https://bmcvetres.biomedcentral.com/counter/pdf/10.1186/s12917-018-1475-3.pdf |
| Ending Page | 11 |
| Page Count | 11 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17466148 |
| DOI | 10.1186/s12917-018-1475-3 |
| Journal | BMC Veterinary Research |
| Issue Number | 1 |
| Volume Number | 14 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2018-05-02 |
| Access Restriction | Open |
| Subject Keyword | Veterinary Medicine Veterinary Science Zoology Transgenics Maytenus senegalensis Haemonchus contortus In vitro Anthelmintic activity Parasitic nematodes Veterinary Medicine/Veterinary Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Veterinary Medicine |
| Journal Impact Factor | 2.3/2023 |
| 5-Year Journal Impact Factor | 2.6/2023 |
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