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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Peng, Juan Zhang, Yan Zhu, Yiqun Chen, Weilin Chen, Li Ma, Fangyu Yi, Bin Huang, Zhijun |
| Abstract | Background Evidence suggests that insulin resistance (IR) is an autonomous risk factor for cardiovascular disease (CVD). Nevertheless, the association between estimated glucose disposal rate (eGDR), a novel indicator of IR, and incident CVD and mortality in chronic kidney disease (CKD) patients without diabetes remains uncertain. Methods The study included 19,906 participants from the UK Biobank who had an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2 or a urinary albumin-to-creatinine ratio (UACR) ≥ 30 mg/g and no history of CVD and diabetes. Individuals were divided into three categories based on tertiles of eGDR. The outcome was a composite CVD (coronary heart disease (CHD) and stroke) and mortality (all-cause, non-accidental, and cardiovascular mortality). Furthermore, a cohort of 1,600 individuals from the US National Health and Nutrition Examination Survey (NHANES) was applied to validate the association between eGDR and mortality. The Cox proportional hazards regression models were used to examine the association between eGDR and event outcomes. Results During a follow-up of around 12 years, 2,860 CVD, 2,249 CHD, 783 stroke, 2,431 all-cause, 2,326 non-accidental and 492 cardiovascular deaths were recorded from UK Biobank. Higher eGDR level was not only associated with lower risk of CVD (hazard ratio [HR] 0.641, 95% confidence interval [CI] 0.559–0.734), CHD (HR 0.607, 95% CI 0.520–0.709), stroke (HR 0.748, 95% CI 0.579–0.966), but also related to reduced risk of all-cause (HR 0.803, 95% CI 0.698–0.923), non-accidental (HR 0.787, 95% CI 0.682–0.908), and cardiovascular mortality (HR 0.592, 95% CI 0.423–0.829). Validation analyses from NHANES yielded consistent relationship on mortality. Conclusions In these two large cohorts of CKD patients without DM, a higher eGDR level was associated with a decreased risk of CVD and mortality. |
| Related Links | https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-024-03582-x.pdf |
| Ending Page | 12 |
| Page Count | 12 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17417015 |
| DOI | 10.1186/s12916-024-03582-x |
| Journal | BMC Medicine |
| Issue Number | 1 |
| Volume Number | 22 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2024-09-27 |
| Access Restriction | Open |
| Subject Keyword | Medicine Public Health Biomedicine Estimated glucose disposal rate Chronic kidney disease Cardiovascular events Mortality Medicine/Public Health |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
| Journal Impact Factor | 7.1/2023 |
| 5-Year Journal Impact Factor | 8.8/2023 |
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