| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Al-Zayadi, Fouad Qasim Jubair Shakir, Ali S. Kareem, Ahmed Shayaa Ghasemian, Abdolmajid Behmard, Esmaeil |
| Abstract | Marburg virus (MARV) is a highly contagious and virulent agent belonging to Filoviridae family. MARV causes severe hemorrhagic fever in humans and non-human primates. Owing to its highly virulent nature, preventive approaches are promising for its control. There is currently no approved drug or vaccine against MARV, and management mainly involves supportive care to treat symptoms and prevent complications. Our aim was to design a novel multi-epitope vaccine (MEV) against MARV using immunoinformatics studies. In this study, various proteins (VP35, VP40 and glycoprotein precursor) were used and potential epitopes were selected. CTL and HTL epitopes covered 79.44% and 70.55% of the global population, respectively. The designed MEV construct was stable and expressed in Escherichia coli (E. coli) host. The physicochemical properties were also acceptable. MARV MEV candidate could predict comprehensive immune responses such as those of humoral and cellular in silico. Additionally, efficient interaction to toll-like receptor 3 (TLR3) and its agonist (β-defensin) was predicted. There is a need for validation of these results using further in vitro and in vivo studies. |
| Related Links | https://bmcbiotechnol.biomedcentral.com/counter/pdf/10.1186/s12896-024-00873-2.pdf |
| Ending Page | 13 |
| Page Count | 13 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14726750 |
| DOI | 10.1186/s12896-024-00873-2 |
| Journal | BMC Biotechnology |
| Issue Number | 1 |
| Volume Number | 24 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2024-07-05 |
| Access Restriction | Open |
| Subject Keyword | Applied Microbiology Biotechnology Biochemical Engineering Genetic Engineering Plant Breeding Biomedical Engineering Marburg virus Multi-epitope vaccine Prevention immunization In silico Plant Breeding/Biotechnology Biomedical Engineering/Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biotechnology |
| Journal Impact Factor | 3.5/2023 |
| 5-Year Journal Impact Factor | 3.2/2023 |
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