| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Waldmann, Marco Bohner, Marc Le, Long-Quan R. V. Baghnavi, Anna Riedel, Bianca Seidenstuecker, Michael |
| Abstract | β-TCP ceramics are versatile bone substitute materials and show many interactions with cells of the monocyte-macrophage-lineage. The possibility of monocytes entering microporous β-TCP ceramics has however not yet been researched. In this study, we used a model approach to investigate whether monocytes might enter β-TCP, providing a possible explanation for the origin of CD68-positive osteoclast-like giant cells found in earlier works.We used flow chambers to unidirectionally load BC, PRP, or PPP into slice models of either 2 mm or 6 mm β-TCP. Immunofluorescence for CD68 and live/dead staining was performed after the loading process.Our results show that monocytes were present in a relevant number of PRP and BC slices representing the inside of our 2 mm slice model and also present on the actual inside of our 6 mm model. For PPP, monocytes were not found beyond the surface in either model.Our results indicate the possibility of a new and so far neglected constituent in β-TCP degradation, perhaps causing the process of ceramic degradation also starting from inside the ceramics as opposed to the current understanding. We also demonstrated flow chambers as a possible new in vitro model for interactions between blood and β-TCP. |
| Related Links | https://bmcbiotechnol.biomedcentral.com/counter/pdf/10.1186/s12896-024-00857-2.pdf |
| Ending Page | 11 |
| Page Count | 11 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14726750 |
| DOI | 10.1186/s12896-024-00857-2 |
| Journal | BMC Biotechnology |
| Issue Number | 1 |
| Volume Number | 24 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2024-05-15 |
| Access Restriction | Open |
| Subject Keyword | Applied Microbiology Biotechnology Biochemical Engineering Genetic Engineering Plant Breeding Biomedical Engineering β-TCP PRP Ceramic Monocyte Immunofluorescence Live/Dead Degradation Plant Breeding/Biotechnology Biomedical Engineering/Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biotechnology |
| Journal Impact Factor | 3.5/2023 |
| 5-Year Journal Impact Factor | 3.2/2023 |
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