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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Asadi, Mohammad Reza Gharesouran, Jalal Sabaie, Hani Moslehian, Marziyeh Sadat Dehghani, Hossein Arsang-Jang, Shahram Taheri, Mohammad Mortazavi, Deniz Hussen, Bashdar Mahmud Sayad, Arezou Rezazadeh, Maryam |
| Abstract | Schizophrenia (SCZ) is a severe mental disorder with an unknown pathophysiology. Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin that has been associated with synapse plasticity, learning, and memory, as well as neurodevelopment and neuroprotection. The importance of neurodevelopmental and neurotoxicity-related components in the pathophysiology of SCZ has been highlighted in research on the neurobiology of this disease. The purpose of this research is to investigate the significant expression of two variables, tristetraprolin (TTP) and miR-16, which are known to be regulators of BDNF expression. Fifty Iranian Azeri SCZ patients were enrolled, and fifty healthy volunteers were age- and gender-matched as controls. A quantitative polymerase chain reaction measured the expression levels of the TTP and miR-16 in the peripheral blood (PB) of SCZ patients and healthy people. TTP expression levels in patients were higher than in controls, regardless of gender or age (posterior beta = 1.532, adjusted P-value = 0.012). TTP and miR-16 expression levels were found to be significantly correlated in both SCZ patients and healthy controls (r = 0.701, P < 0.001 and r = 0.777, P < 0.001, respectively). Due to the increased expression of TTP in SCZ and the existence of a significant correlation between TTP and miR-16, which helps to act on target mRNAs with AU-rich elements, this mechanism can be considered an influencing factor in SCZ. |
| Related Links | https://bmcpsychiatry.biomedcentral.com/counter/pdf/10.1186/s12888-022-04442-9.pdf |
| Ending Page | 10 |
| Page Count | 10 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s12888-022-04442-9 |
| Journal | BMC Psychiatry |
| Issue Number | 1 |
| Volume Number | 22 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2022-12-08 |
| Access Restriction | Open |
| Subject Keyword | Psychiatry Psychotherapy Schizophrenia TTP miR-16 Expression BDNF AU-rich elements qPCR |
| Content Type | Text |
| Resource Type | Article |
| Subject | Psychiatry and Mental Health |
| Journal Impact Factor | 3.4/2023 |
| 5-Year Journal Impact Factor | 4.2/2023 |
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