NDLI: Intraventricular hemorrhage among very low birth weight infants in a South African cohort: a retrospective study of trends & short-term outcomes

Content Provider	Springer Nature : BioMed Central
Author	Akuamoah-Boateng, Gloria Moon, Troy D. Amorim, Gustavo Bandini, Rossella Ballot, Daynia
Abstract	Background Intraventricular hemorrhage (IVH) is one of the critical complications of prematurity with severe forms, associated with irreversible brain damage. We hypothesized that infants born in South Africa may have different modifiable risk factors and outcomes for severe IVH compared to that reported in studies in neonatal populations in higher resource settings. Our study aimed to define the prevalence of IVH with further characterization of risk factors based on IVH severity, with the goal of providing guidance on modification of protocols for the management and prevention of severe IVH. Methods This was a retrospective cohort study of very low birth weight infants admitted to the NICU of Charlotte Maxeke Academic Hospital in Johannesburg (CMJAH) from January 1, 2016, to December 31, 2020. Our study included all infants, weighing less than 1500 g, admitted to the hospital regardless of place of birth who had had at least one cranial ultrasound in the first week of life. Infants with other intracranial malformations than IVH, birth weights greater than 1500 g, and significant amount of missing data were excluded from the study. Maternal and neonatal information were extracted from an existing neonatal database and analyzed using R statistical software. Multivariable logistic regressions were used to investigate risk factors associated with increased odds of having IVH and its impact on mortality. Results A total of 2,217 very low birthweight (VLBW) infants admitted to the NICU at CMJAH during the study period met eligibility criteria. Median gestational age (GA) and birth weight (BW) were 28 weeks and 900 g, respectively. IVH prevalence was 22.6% with high grade IVH (grade 3 or 4) accounting for 6.8% of the cases. Infants with high grade IVH had 4-fold increase odds of dying (OR = 4.843, 95% CI = 2.984; 7.86, p < 0.001). Acidosis was associated with increased odds of high grade IVH (OR = 2.27; 95%CI: 1.42; 3.64). Similarly, infants with early onset sepsis had higher odds of high grade IVH (OR = 2.22; 95%CI: 1.04; 4.75). Conclusions Acidosis and sepsis had a significant association with the occurrence of severe IVH. Antenatal steroids showed an association with occurrence and severity suggesting it may play an important role, but did not reach significance so must be further evaluated. Having severe IVH substantially increased the odds of death. Based on these findings, future directions could include collaborative QI projects with obstetricians to improve uptake of antenatal steroids and promotion of neonatology led QI projects to reduce risk factors associated with severe IVH.
Related Links	https://bmcpediatr.biomedcentral.com/counter/pdf/10.1186/s12887-025-05426-w.pdf
Ending Page	9
Page Count	9
Starting Page	1
File Format	HTM / HTML
ISSN	14712431
DOI	10.1186/s12887-025-05426-w
Journal	BMC Pediatrics
Issue Number	1
Volume Number	25
Language	English
Publisher	BioMed Central
Publisher Date	2025-02-25
Access Restriction	Open
Subject Keyword	Pediatrics Internal Medicine Intraventricular hemorrhage Very low birth weight Prematurity South Africa
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health
Journal Impact Factor	2/2023
5-Year Journal Impact Factor	2.4/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Risk factors for early periventricular intraventricular hemorrhage in extremely low birth weight infants: a retrospective study

Risk factors associated with anemia of prematurity requiring red blood cell transfusion in very low birth weight infants: a retrospective study

7 Cumulative Hypercapnia and Risk of Intraventricular Hemorrhage Among Very Low Birth Weight Infants

Care practices and short-term clinical outcomes of very low birth weight infants in Yangtze River Delta in China

INTRAPARTUM FACTORS AND INTRAVENTRICULAR HEMORRHAGE (IVH) IN VERY LOW BIRTH WEIGHT (VLBW) INFANTS

Skin blood flow as a predictor of intraventricular hemorrhage in very-low-birth-weight infants

Association between admission hypothermia and outcomes in very low birth weight infants in China: a multicentre prospective study

Early neurodevelopment in very low birth weight infants with mild intraventricular hemorrhage or those without intraventricular hemorrhage

Growth of a cohort of very low birth weight infants in Johannesburg, South Africa

Intraventricular hemorrhage among very low birth weight infants in a South African cohort: a retrospective study of trends & short-term outcomes

Similar Documents

Risk factors for early periventricular intraventricular hemorrhage in extremely low birth weight infants: a retrospective study

Risk factors associated with anemia of prematurity requiring red blood cell transfusion in very low birth weight infants: a retrospective study

7 Cumulative Hypercapnia and Risk of Intraventricular Hemorrhage Among Very Low Birth Weight Infants

Care practices and short-term clinical outcomes of very low birth weight infants in Yangtze River Delta in China

INTRAPARTUM FACTORS AND INTRAVENTRICULAR HEMORRHAGE (IVH) IN VERY LOW BIRTH WEIGHT (VLBW) INFANTS

Skin blood flow as a predictor of intraventricular hemorrhage in very-low-birth-weight infants

Association between admission hypothermia and outcomes in very low birth weight infants in China: a multicentre prospective study

Early neurodevelopment in very low birth weight infants with mild intraventricular hemorrhage or those without intraventricular hemorrhage

Growth of a cohort of very low birth weight infants in Johannesburg, South Africa

Intraventricular hemorrhage among very low birth weight infants in a South African cohort: a retrospective study of trends & short-term outcomes