NDLI: Ocular transient receptor potential channel function in health and disease

Content Provider	Springer Nature : BioMed Central
Author	Reinach, Peter S. Mergler, Stefan Okada, Yuka Saika, Shizuya
Abstract	Transient receptor potential (TRP) channels sense and transduce environmental stimuli into Ca2+ transients that in turn induce responses essential for cell function and adaptation. These non-selective channels with variable Ca2+ selectivity are grouped into seven different subfamilies containing 28 subtypes based on differences in amino acid sequence homology. Many of these subtypes are expressed in the eye on both neuronal and non-neuronal cells where they affect a host of stress-induced regulatory responses essential for normal vision maintenance. This article reviews our current knowledge about the expression, function and regulation of TRPs in different eye tissues. We also describe how under certain conditions TRP activation can induce responses that are maladaptive to ocular function. Furthermore, the possibility of an association between TRP mutations and disease is considered. These findings contribute to evidence suggesting that drug targeting TRP channels may be of therapeutic benefit in a clinical setting. We point out issues that must be more extensively addressed before it will be possible to decide with certainty that this is a realistic endeavor. Another possible upshot of future studies is that disease process progression can be better evaluated by profiling changes in tissue specific functional TRP subtype activity as well as their gene and protein expression.
Related Links	https://bmcophthalmol.biomedcentral.com/counter/pdf/10.1186/s12886-015-0135-7.pdf
Ending Page	40
Page Count	12
Starting Page	29
File Format	HTM / HTML
ISSN	14712415
DOI	10.1186/s12886-015-0135-7
Journal	BMC Ophthalmology
Issue Number	1
Volume Number	15
Language	English
Publisher	BioMed Central
Publisher Date	2015-12-17
Access Restriction	Open
Subject Keyword	Ophthalmology Transient receptor potential ion channels Calcium Retina Cornea Uvea Lens
Content Type	Text
Resource Type	Article
Subject	Ophthalmology
Journal Impact Factor	1.7/2023
5-Year Journal Impact Factor	2/2023

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