NDLI: A novel histopathologic finding in the Descemet's membrane of a patient with Peters Anomaly: a case-report and literature review

Content Provider	Springer Nature : BioMed Central
Author	Ni, Wei Wang, Wei Hong, Jing Zhang, Pei Liu, Cong
Abstract	Background Peters anomaly is a rare developmental abnormality of the anterior segment of the eye and is one of the main causes of congenital corneal opacities. Typically, histopathology of Peters anomaly shows immature or absent Descemet’s membrane and attenuated endothelial cells in the area of the corneal opacity, in addition to thinning or absence of Bowman’s membrane and defects in the posterior stroma. In this report, we present a novel histopathological finding, which has not been previously reported, in the Descemet's membrane of a patient who is clinically diagnosed with Peters anomaly. Case presentation A 7-years old female child with developmentally delayed was born of a normal pregnancy, labor, and delivery. Apparent bilateral corneal opacifications were present at birth. On ophthalmologic examination, the child had a visual acuity of FC/20 cm in the right eye and that of FC/10 cm in the left one. Horizontal nystagmus and congenital cataract were found in both eyes. Slit-lamp examination revealed bilateral central corneal opacities which covered the iris and pupils. High-frequency UBM and AS-OCT both showed a shallow anterior chamber with multiple areas of iridocorneal adhesions and no corneal lenticular touch in each eye. A corneal specialist performed a penetrating keratoplasty with extra-capsular cataract extraction and intraocular lens implantation. Histopathologic procedures were conducted on the host corneal button, including Hematoxylin-Eosin stain and Periodic Acid-Schiff stain. All the sections were examined by light microscopy. Conclusion The “multiple-layer” structure of the Descemet’s membrane described in our case has not been reported before as in association with abnormalities of the cornea tissues in Peters anomaly. Such pathological finding need to be reported to enhance further understanding of the special structure of Descemet's membrane as an abnormality during embryogenesis and neural crest cell differentiations.
Related Links	https://bmcophthalmol.biomedcentral.com/counter/pdf/10.1186/s12886-015-0131-y.pdf
Ending Page	5
Page Count	5
Starting Page	1
File Format	HTM / HTML
ISSN	14712415
DOI	10.1186/s12886-015-0131-y
Journal	BMC Ophthalmology
Issue Number	1
Volume Number	15
Language	English
Publisher	BioMed Central
Publisher Date	2015-10-23
Access Restriction	Open
Subject Keyword	Ophthalmology Peters anomaly Descemet's membrane Anterior segment dysgenesis Corneal opacity
Content Type	Text
Resource Type	Case study
Subject	Ophthalmology
Journal Impact Factor	1.7/2023
5-Year Journal Impact Factor	2/2023

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