NDLI: Maternal exposure to life events during pregnancy and congenital heart disease in offspring: a case-control study in a Chinese population

Content Provider	Springer Nature : BioMed Central
Author	Li, Jing Du, Yujiao Liu, Yini Du, Jiaoyang Zhang, Ruo Qu, Pengfei Yan, Hong Wang, Duolao Dang, Shaonong
Abstract	Background Previous studies have suggested that maternal stress could increase the risk of some adverse pregnancy outcomes, but evidence on congenital heart disease (CHD) is limited. We aimed to explore the association between maternal exposure to life events during pregnancy and CHD in offspring. Methods The data was based on an unmatched case-control study about CHD conducted in Shaanxi province of China from 2014 to 2016. We included 2280 subjects, 699 in the case group and 1581 in the control group. The cases were infants or fetuses diagnosed with CHD, and the controls were infants without any birth defects. The life events were assessed by the Life Events Scale for Pregnant Women, and were divided into positive and negative events for synchronous analysis. A directed acyclic graph was drawn to screen the confounders. Logistic regression was employed to estimate the odds ratio and 95% confidence interval for the effects of life events on CHD. Results After controlling for the potential confounders, the pregnant women experiencing the positive events during pregnancy had lower risk of CHD in offspring than those without positive events (OR = 0.38, 95%CI: 0.30 ~ 0.48). The risk of CHD in offspring could increase by 62% among the pregnant women experiencing the negative events compared to those without (OR = 1.62, 95%CI: 1.29 ~ 2.03). Both effects showed a certain dose-response association. Besides, the positive events could weaken the risk impact of negative events on CHD. Conclusion It may suggest that maternal exposure to negative life events could increase the risk of CHD in offspring, while experiencing positive events could play a potential protective role.
Related Links	https://bmcpregnancychildbirth.biomedcentral.com/counter/pdf/10.1186/s12884-021-04154-0.pdf
Ending Page	10
Page Count	10
Starting Page	1
File Format	HTM / HTML
ISSN	14712393
DOI	10.1186/s12884-021-04154-0
Journal	BMC Pregnancy and Childbirth
Issue Number	1
Volume Number	21
Language	English
Publisher	BioMed Central
Publisher Date	2021-10-06
Access Restriction	Open
Subject Keyword	Reproductive Medicine Maternal and Child Health Gynecology Life events Congenital heart disease Case-control study
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology
Journal Impact Factor	2.8/2023
5-Year Journal Impact Factor	3.4/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Risk-prediction nomogram for congenital heart disease in offspring of Chinese pregnant women

Maternal periconceptional environmental exposure and offspring with congenital heart disease: a case–control study in Guangzhou, China

Maternal cardiovascular health in early pregnancy and the risk of congenital heart defects in offspring

Association of maternal phthalates exposure and metabolic gene polymorphisms with congenital heart diseases: a multicenter case-control study

The impact of maternal intrahepatic cholestasis during pregnancy on the growth trajectory of offspring: a population-based nested case‒control cohort study

Association of MTHFD1 gene polymorphisms and maternal smoking with risk of congenital heart disease: a hospital-based case-control study

Associations between maternal social support and stressful life event with ventricular septal defect in offspring: a case-control study

Congenital heart disease in men – birth characteristics and reproduction: a national cohort study

Association analysis of maternal exposure to air pollution during pregnancy and offspring asthma incidence

Maternal exposure to life events during pregnancy and congenital heart disease in offspring: a case-control study in a Chinese population

Similar Documents

Risk-prediction nomogram for congenital heart disease in offspring of Chinese pregnant women

Maternal periconceptional environmental exposure and offspring with congenital heart disease: a case–control study in Guangzhou, China

Maternal cardiovascular health in early pregnancy and the risk of congenital heart defects in offspring

Association of maternal phthalates exposure and metabolic gene polymorphisms with congenital heart diseases: a multicenter case-control study

The impact of maternal intrahepatic cholestasis during pregnancy on the growth trajectory of offspring: a population-based nested case‒control cohort study

Association of MTHFD1 gene polymorphisms and maternal smoking with risk of congenital heart disease: a hospital-based case-control study

Associations between maternal social support and stressful life event with ventricular septal defect in offspring: a case-control study

Congenital heart disease in men – birth characteristics and reproduction: a national cohort study

Association analysis of maternal exposure to air pollution during pregnancy and offspring asthma incidence

Maternal exposure to life events during pregnancy and congenital heart disease in offspring: a case-control study in a Chinese population