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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Xu, Hao-Ming Zhao, Hai-Lan Guo, Gong-Jing Xu, Jing Zhou, You-Lian Huang, Hong-Li Nie, Yu-Qiang |
| Abstract | Background Studies investigating the changes in short-chain fatty acids (SCFAs) in patients with ulcerative colitis (UC) have yielded inconsistent results. We performed a meta-analysis of studies that investigated the alterations in different SCFAs among UC patients to assess their role in the development of UC. Methods Three databases were searched for relevant studies published as of April 2021. Results are presented as standardized mean difference (SMD) with 95% confidence interval (95% CI). Results Eleven studies were included in the meta-analysis. Compared to healthy subjects, UC patients had significantly lower concentrations of total SCFAs (SMD = − 0.88, 95%CI − 1.44, − 0.33; P < 0.001), acetate (SMD = − 0.54, 95% CI − 0.91, − 0.17; P = 0.004), propionate, (SMD = − 0.37, 95% CI − 0.66, − 0.07; P = 0.016), and valerate (SMD = − 0.91, 95% CI − 1.45, − 0.38; P < 0.001). On subgroup analysis based on disease status, patients with active UC had reduced concentrations of acetate (SMD = − 1.83, 95% CI − 3.32, − 0.35; P = 0.015), propionate (SMD = − 2.51, 95% CI − 4.41, − 0.61; P = 0.009), and valerate (SMD = − 0.91, 95% CI − 1.45, − 0.38; P < 0.001), while UC patients in remission had similar concentrations with healthy subjects. Patients with active UC had lower butyrate level (SMD = − 2.09, 95% CI − 3.56, − 0.62; P = 0.005) while UC patients in remission had higher butyrate level (SMD = 0.71, 95% CI 0.33, 1.10; P < 0.001) compared with healthy subjects. Conclusion UC patients had significantly decreased concentrations of total SCFAs, acetate, propionate, and valerate compared with healthy subjects. In addition, inconsistent changes of certain special SCFAs were observed in UC patients with different disease status. |
| Related Links | https://bmcgastroenterol.biomedcentral.com/counter/pdf/10.1186/s12876-022-02191-3.pdf |
| Ending Page | 9 |
| Page Count | 9 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s12876-022-02191-3 |
| Journal | BMC Gastroenterology |
| Issue Number | 1 |
| Volume Number | 22 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2022-03-10 |
| Access Restriction | Open |
| Subject Keyword | Gastroenterology Internal Medicine Hepatology Short-chain fatty acids Ulcerative colitis Meta-analysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology |
| Journal Impact Factor | 2.5/2023 |
| 5-Year Journal Impact Factor | 2.7/2023 |
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