NDLI: Genome-wide association study exploring the genetic architecture of eggshell speckles in laying hens

Content Provider	Springer Nature : BioMed Central
Author	Cheng, Xue Li, Xinghua Yang, Mengyuan Zheng, Chuanwei Li, Haiying Qu, Lujiang Ning, Zhonghua
Abstract	Background Eggshell speckle phenotype is an important trait in poultry production because they affect eggshell quality. However, the genetic architecture of speckled eggshells remains unclear. In this study, we determined the heritability of eggshell speckles and conducted a genome-wide association study (GWAS) on purebred Rhode Island Red (RIR) hens at 28 weeks to detect potential genomic loci and candidate genes associated with eggshell speckles. Results The heritability of eggshell speckles was 0.35 at 28 weeks, and the speckle level is not related to other eggshell quality traits in terms of phenotypic correlation. We detected 311 SNPs (6 significantly, and 305 suggestively associated) and 39 candidate genes associated with eggshell speckles. Based on the pathway analysis, the 39 candidate genes were mainly involved in alpha-linolenic acid metabolism, linoleic acid metabolism, ether lipid metabolism, GnRH signaling pathway, vascular smooth muscle contraction, and MAPK signaling pathway. Ultimately, ten genes, LOC423226, SPTBN5, EHD4, LOC77155, TYRO3, ITPKA, DLL4, PLA2G4B, PLA2G4EL5, and PLA2G4EL6 were considered the most promising genes associated with eggshell speckles that were implicated in immunoregulation, calcium transport, and phospholipid metabolism, while its function in laying hens requires further studies. Conclusions This study provides new insights into understanding the genetic basis of eggshell speckles and has practical application value for the genetic improvement of eggshell quality.
Related Links	https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-023-09632-7.pdf
Ending Page	8
Page Count	8
Starting Page	1
File Format	HTM / HTML
ISSN	14712164
DOI	10.1186/s12864-023-09632-7
Journal	BMC Genomics
Issue Number	1
Volume Number	24
Language	English
Publisher	BioMed Central
Publisher Date	2023-11-22
Access Restriction	Open
Subject Keyword	Life Sciences Microarrays Proteomics Animal Genetics and Genomics Microbial Genetics and Genomics Plant Genetics and Genomics Laying hens Eggshell speckles Egg quality GWAS
Content Type	Text
Resource Type	Article
Subject	Biotechnology Genetics
Journal Impact Factor	3.5/2023
5-Year Journal Impact Factor	4.1/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Genome-wide association study dissects genetic architecture underlying longitudinal egg weights in chickens

Genetic variations for the eggshell crystal structure revealed by genome-wide association study in chickens

Genome-wide association study (GWAS) reveals the genetic architecture of four husk traits in maize

Genome-wide selective signatures mining the candidate genes for egg laying in goose

Genome-wide association study revealed a promising region and candidate genes for eggshell quality in an F2 resource population

Genome-wide association study reveals the genetic architecture of root hair length in maize

Genome-wide association study of quality traits and starch pasting properties of maize kernels

Identification of candidate genomic regions for chicken egg number traits based on genome-wide association study

Genetic architecture of cyst nematode resistance revealed by genome-wide association study in soybean

Genome-wide association study exploring the genetic architecture of eggshell speckles in laying hens

Similar Documents

Genome-wide association study dissects genetic architecture underlying longitudinal egg weights in chickens

Genetic variations for the eggshell crystal structure revealed by genome-wide association study in chickens

Genome-wide association study (GWAS) reveals the genetic architecture of four husk traits in maize

Genome-wide selective signatures mining the candidate genes for egg laying in goose

Genome-wide association study revealed a promising region and candidate genes for eggshell quality in an F2 resource population

Genome-wide association study reveals the genetic architecture of root hair length in maize

Genome-wide association study of quality traits and starch pasting properties of maize kernels

Identification of candidate genomic regions for chicken egg number traits based on genome-wide association study

Genetic architecture of cyst nematode resistance revealed by genome-wide association study in soybean

Genome-wide association study exploring the genetic architecture of eggshell speckles in laying hens