NDLI: Catecholamine concentration as a predictor of mortality in emergency surgical patients

Content Provider	Springer Nature : BioMed Central
Author	Suh, João Isuk da Roza, Daiane Leite Cadamuro, Filipe Matheus Malbouisson, Luiz Marcelo Sá Sanches, Talita Rojas Andrade, Lúcia
Abstract	Background Trauma and emergency surgery are major causes of morbidity and mortality. The objective of this study was to determine whether serum levels of epinephrine and norepinephrine are associated with aging and mortality. Methods This was a prospective observational cohort study conducted in a surgical critical care unit. We included 90 patients who were admitted for postoperative care, because of major trauma, or both. We collected demographic and clinical variables, as well as serum levels of epinephrine and norepinephrine. Results For patients in the > 60-year age group, the use of vasoactive drugs was found to be associated with an undetectable epinephrine level (OR [95% CI] = 6.36 [1.12, 36.08]), p = 0.05). For the patients with undetectable epinephrine levels, the in-hospital mortality was higher among those with a norepinephrine level ≥ 2006.5 pg/mL (OR [95% CI] = 4.00 [1.27, 12.58]), p = 0.03). Conclusions There is an association between age and mortality. Undetectable serum epinephrine, which is more common in older patients, could contribute to poor outcomes. The use of epinephrine might improve the clinical prognosis in older surgical patients with shock.
Related Links	https://intjem.biomedcentral.com/counter/pdf/10.1186/s12245-024-00676-4.pdf
Ending Page	7
Page Count	7
Starting Page	1
File Format	HTM / HTML
ISSN	18651380
DOI	10.1186/s12245-024-00676-4
Journal	International Journal of Emergency Medicine
Issue Number	1
Volume Number	17
Language	English
Publisher	BioMed Central
Publisher Date	2024-07-18
Access Restriction	Open
Subject Keyword	Emergency Medicine Internal Medicine Cardiology Angiology Pediatrics Norepinephrine Epinephrine SOFA SAPS ICU outcome Vasopressors Mortality
Content Type	Text
Resource Type	Article
Subject	Emergency Medicine

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