NDLI: A pilot study of a new test to predict extubation failure

Content Provider	Springer Nature : BioMed Central
Author	Solsona, José F Díaz, Yolanda Vázquez, Antonia Pilar Gracia, Maria Zapatero, Ana Marrugat, Jaume
Abstract	Introduction To determine whether subjecting patients to 100 ml of additional dead space after a 120-minute weaning trial could predict readiness for extubation. Methods This was a prospective, non-randomised pilot study in an intensive care unit at a university hospital with 14 beds. It included all non-tracheostomised patients with improvement of the underlying cause of acute respiratory failure, and those with no need for vasoactive or sedative drugs were eligible. Patients fulfilling the Consensus Conference on Weaning extubation criteria after 120 minutes spontaneous breathing (n = 152) were included. To the endotracheal tube, 100 cc dead space was added for 30 minutes. Patients tolerating the test were extubated; those not tolerating it received six hours of supplementary ventilation before extubation. The measurements taken and main results were: arterial pressure, heart rate, respiratory rate, oxygen saturation, end-tidal carbon dioxide and signs of respiratory insufficiency were recorded every five minutes; and arterial blood gases were measured at the beginning and end of the test. Extubation failure was defined as the need for mechanical and non-invasive ventilation within 48 hours of extubation. Results Twenty-two patients (14.5%) experienced extubation failure. Only intercostal retraction was independently associated with extubation failure. The sensitivity (40.9%) and specificity (97.7%) yield a probability of extubation failure of 75.1% for patients not tolerating the test versus 9.3% for those tolerating it. Conclusions Observing intercostal retraction after adding dead space may help detect susceptibility to extubation failure. The ideal amount of dead space remains to be determined. Trial registration Current Controlled Trials ISRCTN76206152.
Related Links	https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc7783.pdf
Ending Page	9
Page Count	9
Starting Page	1
File Format	HTM / HTML
ISSN	13648535
DOI	10.1186/cc7783
Journal	Critical Care
Issue Number	2
Volume Number	13
Language	English
Publisher	BioMed Central
Publisher Date	2009-04-14
Access Restriction	Open
Subject Keyword	Intensive Critical Care Medicine Emergency Medicine Chronic Obstructive Pulmonary Disease Patient Dead Space Spontaneous Breathing Simplify Acute Physiology Score Noninvasive Ventilation
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine
Journal Impact Factor	8.8/2023
5-Year Journal Impact Factor	10.4/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Noninvasive ventilation immediately after extubation improves weaning outcome after acute respiratory failure: a randomized controlled trial

Profile of reintubated patients submitted to daily weaning screen and spontaneous breathing trial in a general ICU

Another step for noninvasive ventilation in chronic obstructive pulmonary disease patients!

Noninvasive positive pressure ventilation for respiratory failure caused by exacerbations of chronic obstructive pulmonary disease: a standard of care?

Comparative Effectiveness of Noninvasive and Invasive Ventilation in Critically Ill Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease*

Noninvasive mechanical ventilation during the weaning process: facilitative, curative, or preventive?

Functional respiratory effects of noninvasive ventilation in acute hypercapnic patients with chronic obstructive pulmonary disease

Effect of corticosteroids on the clinical course of community-acquired pneumonia: a randomized controlled trial

Lung ultrasound findings predict weaning failure from mechanical ventilation

A pilot study of a new test to predict extubation failure

Similar Documents

Noninvasive ventilation immediately after extubation improves weaning outcome after acute respiratory failure: a randomized controlled trial

Profile of reintubated patients submitted to daily weaning screen and spontaneous breathing trial in a general ICU

Another step for noninvasive ventilation in chronic obstructive pulmonary disease patients!

Noninvasive positive pressure ventilation for respiratory failure caused by exacerbations of chronic obstructive pulmonary disease: a standard of care?

Comparative Effectiveness of Noninvasive and Invasive Ventilation in Critically Ill Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease*

Noninvasive mechanical ventilation during the weaning process: facilitative, curative, or preventive?

Functional respiratory effects of noninvasive ventilation in acute hypercapnic patients with chronic obstructive pulmonary disease

Effect of corticosteroids on the clinical course of community-acquired pneumonia: a randomized controlled trial

Lung ultrasound findings predict weaning failure from mechanical ventilation

A pilot study of a new test to predict extubation failure