NDLI: Fluid balance as a biomarker: impact of fluid overload on outcome in critically ill patients with acute kidney injury

Content Provider	Springer Nature : BioMed Central
Author	Bagshaw, Sean M Brophy, Patrick D Cruz, Dinna Ronco, Claudio
Abstract	Fluid therapy is fundamental to the acute resuscitation of critically ill patients. In general, however, early and appropriate goal-directed fluid therapy contributes to a degree of fluid overload in most if not all patients. Recent data imply that a threshold may exist beyond which, after acute resuscitation, additional fluid therapy may cause harm. In patients with acute kidney injury and/or oliguria, a positive fluid balance is almost universal. Few studies have examined the impact of fluid balance on clinical outcomes in critically ill adults with acute kidney injury. Payen and coworkers, in a secondary analysis of the SOAP (Sepsis Occurrence in Acutely Ill Patients) study, now present evidence that there is an independent association between mortality and positive fluid balance in a cohort of critically ill patients with acute kidney injury. In this commentary, we discuss these findings within the context of prior literature and propose that assessment of fluid balance should be considered as a potentially valuable biomarker of critical illness.
Related Links	https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc6948.pdf
Ending Page	3
Page Count	3
Starting Page	1
File Format	HTM / HTML
ISSN	13648535
DOI	10.1186/cc6948
Journal	Critical Care
Issue Number	4
Volume Number	12
Language	English
Publisher	BioMed Central
Publisher Date	2008-07-24
Access Restriction	Open
Subject Keyword	Intensive Critical Care Medicine Emergency Medicine Acute Kidney Injury Intensive Care Unit Admission Fluid Balance Sequential Organ Failure Assessment Sequential Organ Failure Assessment Score
Content Type	Text
Subject	Critical Care and Intensive Care Medicine
Journal Impact Factor	8.8/2023
5-Year Journal Impact Factor	10.4/2023

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