NDLI: Procalcitonin in liver transplantation: are high levels due to donors or recipients?

Content Provider	Springer Nature : BioMed Central
Author	Eyraud, Daniel Ben Ayed, Saïd Tanguy, Marie Laure Vézinet, Corinne Siksik, Jean Michel Bernard, Maguy Fratéa, Sylvia Movschin, Marie Vaillant, Jean-Christophe Coriat, Pierre Hannoun, Laurent
Abstract	Introduction To date, a specific marker to evaluate and predict the clinical course or complication of the liver-transplanted patient is not available in clinical practice. Increased procalcitonin (PCT) levels have been found in infectious inflammation; poor organ perfusion and high PCT levels in the cardiac donor appeared to predict early graft failure. We evaluated PCT as a predictor of early graft dysfunction and postoperative complications. Methods PCT serum concentrations were measured in samples collected before organ retrieval from 67 consecutive brain-dead donors and in corresponding recipients from day 0, before liver transplantation, up to day 7 after liver transplantation. The following parameters were recorded in donors: amount of vasopressive drug doses, cardiac arrest history 24 hours before retrieval, number of days in the intensive care unit, age of donor, and infection in donor, and the following parameters were recorded in recipients: cold and warm ischemia time, veno-venous bypass, transfusion amount during orthotopic liver transplantation (OLT), and occurrence of postoperative complication or hepatic dysfunction. Results In the donor, the preoperative level of PCT was associated with cardiac arrest and high doses of catecholamines before organ retrieval. In the recipient, elevated PCT levels were observed early after OLT, with a peak at day 1 or 2 after OLT, then a decrease until day 7. A postoperative peak of PCT levels was associated neither with preoperative PCT levels in the donor or the recipients nor with hepatic post-OLT dysfunction or other postoperative complications, but with two donor parameters: infection and cardiac arrest. Conclusion PCT level in the donor and early PCT peak in the recipient are not predictive of post-OLT hepatic dysfunction or other complications. Cardiac arrest and infection in the donor, but not PCT level in the donor, are associated with high post-OLT PCT levels in the recipient.
Related Links	https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc6942.pdf
Ending Page	7
Page Count	7
Starting Page	1
File Format	HTM / HTML
ISSN	13648535
DOI	10.1186/cc6942
Journal	Critical Care
Issue Number	4
Volume Number	12
Language	English
Publisher	BioMed Central
Publisher Date	2008-07-04
Access Restriction	Open
Subject Keyword	Intensive Critical Care Medicine Emergency Medicine Orthotopic Liver Transplantation Hepatic Dysfunction Procalcitonin Liver Graft Graft Dysfunction
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine
Journal Impact Factor	8.8/2023
5-Year Journal Impact Factor	10.4/2023

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