NDLI: In-vivovalidation of a new non-invasive continuous ventricular stroke volume monitoring system in an animal model

Content Provider	Springer Nature : BioMed Central
Author	Konings, Maurits K Grundeman, Paul F Goovaerts, Henk G Roosendaal, Maarten R Hoefer, Imo E Doevendans, Pieter A Rademakers, Frank E Buhre, Wolfgang F
Abstract	Introduction Recently, a non-invasive, continuous ventricular stroke volume monitoring system using skin electrodes has been developed. In contrast to impedance-based methods, the new technique (ventricular field recognition) enables measurement of changes in ventricular volume. A prototype using this new method was built (the hemologic cardiac profiler, HCP) and validated against a reference method in a pig model during variations in cardiac output. Methods In six Dalland pigs, cardiac output was simultaneously measured with the HCP (CO-HCP), and an invasive ultrasonic flow-probe around the ascending aorta (CO-FP). Variations in CO were achieved by change in ventricular loading conditions, cardiac pacing, and dobutamine administration. Data were analysed according to Bland-Altman analysis and Pearson's correlation. Results Pearson's correlation between the CO-HCP and the CO-FP was r = 0.978. Bland-Altman analysis showed a bias of - 0.114 L/minute, and a variability of the bias (2 standard deviations, 2SD) of 0.55 L/minute. Conclusions The results of the present study demonstrate that CO-HCP is comparable to CO-FP in an animal model of cardiac output measurements during a wide variation of CO. Therefore, the HCP has the potential to become a clinical applicable cardiac output monitor.
Related Links	https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc10306.pdf
Ending Page	8
Page Count	8
Starting Page	1
File Format	HTM / HTML
ISSN	13648535
DOI	10.1186/cc10306
Journal	Critical Care
Issue Number	4
Volume Number	15
Language	English
Publisher	BioMed Central
Publisher Date	2011-07-11
Access Restriction	Open
Subject Keyword	Intensive Critical Care Medicine Emergency Medicine Cardiac Output Flow Probe Cardiac Pace Pancuronium Bromide Cardiac Output Monitoring
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine
Journal Impact Factor	8.8/2023
5-Year Journal Impact Factor	10.4/2023

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