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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Samadian, Soroush McManus, Bruce Wilkinson, Mark D |
| Abstract | Background Measurement-unit conflicts are a perennial problem in integrative research domains such as clinical meta-analysis. As multi-national collaborations grow, as new measurement instruments appear, and as Linked Open Data infrastructures become increasingly pervasive, the number of such conflicts will similarly increase. Methods We propose a generic approach to the problem of (a) encoding measurement units in datasets in a machine-readable manner, (b) detecting when a dataset contained mixtures of measurement units, and (c) automatically converting any conflicting units into a desired unit, as defined for a given study. Results We utilized existing ontologies and standards for scientific data representation, measurement unit definition, and data manipulation to build a simple and flexible Semantic Web Service-based approach to measurement-unit harmonization. A cardiovascular patient cohort in which clinical measurements were recorded in a number of different units (e.g., mmHg and cmHg for blood pressure) was automatically classified into a number of clinical phenotypes, semantically defined using different measurement units. Conclusions We demonstrate that through a combination of semantic standards and frameworks, unit integration problems can be automatically detected and resolved. |
| Related Links | https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/1755-8794-7-S1-S12.pdf |
| Ending Page | 8 |
| Page Count | 8 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17558794 |
| DOI | 10.1186/1755-8794-7-S1-S12 |
| Journal | BMC Medical Genomics |
| Issue Number | 1 |
| Volume Number | 7 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2014-05-08 |
| Access Restriction | Open |
| Subject Keyword | Human Genetics Microarrays Gene Expression Resource Description Framework SPARQL Query Resource Description Framework Data Body Mass Index Class Unit Exponentiation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics (clinical) Genetics |
| Journal Impact Factor | 2.1/2023 |
| 5-Year Journal Impact Factor | 2.5/2023 |
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