NDLI: Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer

Content Provider	Springer Nature : BioMed Central
Author	Rye, Morten Beck Bertilsson, Helena Drabløs, Finn Angelsen, Anders Bathen, Tone F Tessem, May-Britt
Abstract	Background Good prognostic tools for predicting disease progression in early stage prostate cancer (PCa) are still missing. Detection of molecular subtypes, for instance by using microarray gene technology, can give new prognostic information which can assist personalized treatment planning. The detection of new subtypes with validation across additional and larger patient cohorts is important for bringing a potential prognostic tool into the clinic. Methods We used fresh frozen prostatectomy tissue of high molecular quality to further explore four molecular subtype signatures of PCa based on Gene Set Enrichment Analysis (GSEA) of 15 selected gene sets published in a previous study. For this analysis we used a statistical test of dependent correlations to compare reference signatures to signatures in new normal and PCa samples, and also explore signatures within and between sample subgroups in the new samples. Results An important finding was the consistent signatures observed for samples from the same patient independent of Gleason score. This proves that the signatures are robust and can surpass a normally high tumor heterogeneity within each patient. Our data did not distinguish between four different subtypes of PCa as previously published, but rather highlighted two groups of samples which could be related to good and poor prognosis based on survival data from the previous study.The poor prognosis group highlighted a set of samples characterized by enrichment of ESC, ERG-fusion and MYC + rich signatures in patients diagnosed with low Gleason score,. The other group consisted of PCa samples showing good prognosis as well as normal samples. Accounting for sample composition (the amount of benign structures such as stroma and epithelial cells in addition to the cancer component) was important to improve subtype assignments and should also be considered in future studies. Conclusion Our study validates a previous molecular subtyping of PCa in a new patient cohort, and identifies a subgroup of PCa samples highly interesting for detecting high risk PCa at an early stage. The importance of taking sample tissue composition into account when assigning subtype is emphasized.
Related Links	https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/1755-8794-7-50.pdf
Ending Page	12
Page Count	12
Starting Page	1
File Format	HTM / HTML
ISSN	17558794
DOI	10.1186/1755-8794-7-50
Journal	BMC Medical Genomics
Issue Number	1
Volume Number	7
Language	English
Publisher	BioMed Central
Publisher Date	2014-08-12
Access Restriction	Open
Subject Keyword	Human Genetics Microarrays Gene Expression Prostate cancer Gleason Subtypes Microarray GSEA
Content Type	Text
Resource Type	Article
Subject	Genetics (clinical) Genetics
Journal Impact Factor	2.1/2023
5-Year Journal Impact Factor	2.5/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer

Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems

Pro-neural transcription factors as cancer markers

Gene profiling suggests a common evolution of bladder cancer subtypes

miRNAs expression signature potentially associated with lymphatic dissemination in locally advanced prostate cancer

Biomarker expression patterns that correlate with high grade features in treatment naive, organ-confined prostate cancer

Molecular sampling of prostate cancer: a dilemma for predicting disease progression

Identifying subtype-specific associations between gene expression and DNA methylation profiles in breast cancer

Detection of tmprss2-erg and tmprss2-egr1 gene fusion in prostate cancer from a Chinese population

Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer

Similar Documents

Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer

Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems

Pro-neural transcription factors as cancer markers

Gene profiling suggests a common evolution of bladder cancer subtypes

miRNAs expression signature potentially associated with lymphatic dissemination in locally advanced prostate cancer

Biomarker expression patterns that correlate with high grade features in treatment naive, organ-confined prostate cancer

Molecular sampling of prostate cancer: a dilemma for predicting disease progression

Identifying subtype-specific associations between gene expression and DNA methylation profiles in breast cancer

Detection of tmprss2-erg and tmprss2-egr1 gene fusion in prostate cancer from a Chinese population

Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer