NDLI: A rabbit osteomyelitis model for the longitudinal assessment of early post-operative implant infections

Content Provider	Springer Nature : BioMed Central
Author	Odekerken, Jim CE Arts, Jacobus JC Surtel, Don AM Walenkamp, Geert HIM Welting, Tim JM
Abstract	Background Implant infection is one of the most severe complications within the field of orthopaedic surgery, associated with an enormous burden for the healthcare system. During the last decades, attempts have been made to lower the incidence of implant-related infections. In the case of cemented prostheses, the use of antibiotic-containing bone cement can be effective. However, in the case of non-cemented prostheses, osteosynthesis and spinal surgery, local antibacterial prophylaxis is not a standard procedure. For the development of implant coatings with antibacterial properties, there is a need for a reliable animal model to evaluate the preventive capacity of such coatings during a specific period of time. Existing animal models generally present a limited follow-up, with a limited number of outcome parameters and relatively large animal numbers in multiple groups. Methods To represent an early post-operative implant infection, we established an acute tibial intramedullary nail infection model in rabbits by contamination of the tibial nail with 3.8 × 105 colony forming units of Staphylococcus aureus. Clinical, haematological and radiological parameters for infection were weekly assessed during a 6-week follow-up with post-mortem bacteriological and histological analyses. Results S. aureus implant infection was confirmed by the above parameters. A saline control group did not develop osteomyelitis. By combining the clinical, haematological, radiological, bacteriological and histological data collected during the experimental follow-up, we were able to differentiate between the control and the infected condition and assess the severity of the infection at sequential timepoints in a parameter-dependent fashion. Conclusion We herein present an acute early post-operative rabbit implant infection model which, in contrast to previously published models, combines improved in-time insight into the development of an implant osteomyelitis with a relatively low amount of animals.
Related Links	https://josr-online.biomedcentral.com/counter/pdf/10.1186/1749-799X-8-38.pdf
Ending Page	13
Page Count	13
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/1749-799X-8-38
Journal	Journal of Orthopaedic Surgery and Research
Issue Number	1
Volume Number	8
Language	English
Publisher	BioMed Central
Publisher Date	2013-11-04
Access Restriction	Open
Subject Keyword	Orthopedics Surgical Orthopedics Staphylococcus aureus Implant infection Osteomyelitis Animal model Rabbit
Content Type	Text
Resource Type	Article
Subject	Surgery Orthopedics and Sports Medicine
Journal Impact Factor	2.8/2023
5-Year Journal Impact Factor	3/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Development of a large animal rabbit model for chronic periprosthetic joint infection

The early infection characterization of septic arthritis by Staphylococcus aureus after anterior cruciate ligament reconstruction in a novel rat model

A systematic review of animal models for Staphylococcus aureus osteomyelitis

Predilection for developing a hematogenous orthopaedic implant-associated infection in older versus younger mice

A new model of implant-related osteomyelitis in the metaphysis of rat tibiae

Microbiology of post-operative wound infection in implant surgery

Novel in vivo mouse model of shoulder implant infection

Biofilm and the effect of sonication in a chronic Staphylococcus epidermidis orthopedic in vivo implant infection model

Osteomyelitis: a descriptive study.

A rabbit osteomyelitis model for the longitudinal assessment of early post-operative implant infections

Similar Documents

Development of a large animal rabbit model for chronic periprosthetic joint infection

The early infection characterization of septic arthritis by Staphylococcus aureus after anterior cruciate ligament reconstruction in a novel rat model

A systematic review of animal models for Staphylococcus aureus osteomyelitis

Predilection for developing a hematogenous orthopaedic implant-associated infection in older versus younger mice

A new model of implant-related osteomyelitis in the metaphysis of rat tibiae

Microbiology of post-operative wound infection in implant surgery

Novel in vivo mouse model of shoulder implant infection

Biofilm and the effect of sonication in a chronic Staphylococcus epidermidis orthopedic in vivo implant infection model

Osteomyelitis: a descriptive study.

A rabbit osteomyelitis model for the longitudinal assessment of early post-operative implant infections