NDLI: The effect of a biphasic injectable bone substitute on the interface strength in a rabbit knee prosthesis model

Content Provider	Springer Nature : BioMed Central
Author	Zampelis, Vasilis Tägil, Magnus Lidgren, Lars Isaksson, Hanna Atroshi, Isam Wang, Jian-Sheng
Abstract	Background In joint prosthetic surgery, various methods are used to provide implant stability. We used an injectable bone substitute, composed of calcium sulfate/hydroxyapatite, as bone defect filler to stabilize a tibia prosthesis in an experimental rabbit model. The aim of the study was to investigate and compare the stability of prosthetic fixation with and without the use of an injectable bone substitute. Methods Sixteen rabbits were used and the tibia prostheses were implanted bilaterally, one side with the prosthesis alone and the other side with the prosthesis and calcium sulfate/hydroxyapatite (Cerament™). The rabbits were randomly divided into two groups and euthanized after 6 and 12 weeks, respectively. The prosthesis was extracted measuring the pull-out force in an Instron tester, and the bone surrounding the former prosthesis site was analyzed by histology, histomorphometry, and micro-computed tomography. Results At 6 weeks no difference in maximum pull-out force was found between the prostheses fixed with or without Cerament™. At 12 weeks the maximum pull-out force for the prostheses with Cerament™ was significantly higher than that for the prostheses without Cerament™ (p = 0.04). The maximum pull-out force at 12 weeks was significantly higher than that at 6 weeks for the prostheses fixed with Cerament™ (p = 0.03) but not for the prostheses without. Conclusion We conclude that early prosthesis-bone interface strength is not influenced by a bone substitute. However, during remodeling, the bone substitute might provide improved mechanical support for the prosthesis. The results support further studies of the use of injectable calcium sulfate/hydroxyapatite in fixation of prosthetic joint implants.
Related Links	https://josr-online.biomedcentral.com/counter/pdf/10.1186/1749-799X-8-25.pdf
Ending Page	7
Page Count	7
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/1749-799X-8-25
Journal	Journal of Orthopaedic Surgery and Research
Issue Number	1
Volume Number	8
Language	English
Publisher	BioMed Central
Publisher Date	2013-07-31
Access Restriction	Open
Subject Keyword	Orthopedics Surgical Orthopedics Injectable bone substitute Hydroxyapatite Calcium sulfate Interface strength Histomorphometry
Content Type	Text
Resource Type	Article
Subject	Surgery Orthopedics and Sports Medicine
Journal Impact Factor	2.8/2023
5-Year Journal Impact Factor	3/2023

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