NDLI: Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness

Content Provider	Springer Nature : BioMed Central
Author	Soderstrom, Ken Poklis, Justin L Lichtman, Aron H
Abstract	Background Previously we have found that cannabinoid treatment of zebra finches during sensorimotor stages of vocal development alters song patterns produced in adulthood. Such persistently altered behavior must be attributable to changes in physiological substrates responsible for song. We are currently working to identify the nature of such physiological changes, and to understand how they contribute to altered vocal learning. One possibility is that developmental agonist exposure results in altered expression of elements of endocannabinoid signaling systems. To test this hypothesis we have studied effects of the potent cannabinoid receptor agonist WIN55212-2 (WIN) on endocannabinoid levels and densities of CB1 immunostaining in zebra finch brain. Results We found that late postnatal WIN treatment caused a long-term global disregulation of both levels of the endocannabinoid, 2-arachidonyl glycerol (2-AG) and densities of CB1 immunostaining across brain regions, while repeated cannabinoid treatment in adults produced few long-term changes in the endogenous cannabinoid system. Conclusions Our findings indicate that the zebra finch endocannabinoid system is particularly sensitive to exogenous agonist exposure during the critical period of song learning and provide insight into susceptible brain areas.
Related Links	https://bmcneurosci.biomedcentral.com/counter/pdf/10.1186/1471-2202-12-3.pdf
Ending Page	10
Page Count	10
Starting Page	1
File Format	HTM / HTML
ISSN	14712202
DOI	10.1186/1471-2202-12-3
Journal	BMC Neuroscience
Issue Number	1
Volume Number	12
Language	English
Publisher	BioMed Central
Publisher Date	2011-01-06
Access Restriction	Open
Subject Keyword	Neurosciences Neurobiology Animal Models Zebra Finch Vocal Learning Staining Density Vocal Development Male Zebra Finch
Content Type	Text
Resource Type	Article
Subject	Neuroscience Cellular and Molecular Neuroscience
Journal Impact Factor	2.4/2023
5-Year Journal Impact Factor	2.9/2023

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