NDLI: Effects of collagen-induced rheumatoid arthritis on amyloidosis and microvascular pathology in APP/PS1 mice

Content Provider	Springer Nature : BioMed Central
Author	Park, Sun Mi Shin, Jin Hee Moon, Gyeong Joon Cho, Sung Ig Lee, Yong Beom Gwag, Byoung Joo
Abstract	Background Evidence suggests that rheumatoid arthritis (RA) may enhance or reduce the progression of Alzheimer's disease (AD). The present study was performed to directly explore the effects of collagen-induced rheumatoid arthritis (CIA) on amyloid plaque formation, microglial activation, and microvascular pathology in the cortex and hippocampus of the double transgenic APP/PS1 mouse model for AD. Wild-type or APP/PS1 mice that received type II collagen (CII) in complete Freund's adjuvant (CFA) at 2 months of age revealed characteristics of RA, such as joint swelling, synovitis, and cartilage and bone degradation 4 months later. Joint pathology was accompanied by sustained induction of IL-1β and TNF-α in plasma over 4 weeks after administration of CII in CFA. Results CIA reduced levels of soluble and insoluble amyloid beta (Aβ) peptides and amyloid plaque formation in the cortex and hippocampus of APP/PS1 mice, which correlated with increased blood brain barrier disruption, Iba-1-positive microglia, and CD45-positive microglia/macrophages. In contrast, CIA reduced vessel density and length with features of microvascular pathology, including vascular segments, thinner vessels, and atrophic string vessels. Conclusions The present findings suggest that RA may exert beneficial effects against Aβ burden and harmful effects on microvascular pathology in AD.
Related Links	https://bmcneurosci.biomedcentral.com/counter/pdf/10.1186/1471-2202-12-106.pdf
Ending Page	12
Page Count	12
Starting Page	1
File Format	HTM / HTML
ISSN	14712202
DOI	10.1186/1471-2202-12-106
Journal	BMC Neuroscience
Issue Number	1
Volume Number	12
Language	English
Publisher	BioMed Central
Publisher Date	2011-10-27
Access Restriction	Open
Subject Keyword	Neurosciences Neurobiology Animal Models Amyloidosis Tg2576 Mouse Cerebrovascular Pathology Amyloid Plaque Formation Microvascular Pathology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Cellular and Molecular Neuroscience
Journal Impact Factor	2.4/2023
5-Year Journal Impact Factor	2.9/2023

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