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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Whelan, Fiona J Meehan, Conor J Golding, G Brian McConkey, Brendan J E Bowdish, Dawn M |
| Abstract | Background The class A scavenger receptors are a subclass of a diverse family of proteins defined based on their ability to bind modified lipoproteins. The 5 members of this family are strikingly variable in their protein structure and function, raising the question as to whether it is appropriate to group them as a family based on their ligand binding abilities. Results To investigate these relationships, we defined the domain architecture of each of the 5 members followed by collecting and annotating class A scavenger receptor mRNA and amino acid sequences from publicly available databases. Phylogenetic analyses, sequence alignments, and permutation tests revealed a common evolutionary ancestry of these proteins, indicating that they form a protein family. We postulate that 4 distinct gene duplication events and subsequent domain fusions, internal repeats, and deletions are responsible for the diverse protein structures and functions of this family. Despite variation in domain structure, there are highly conserved regions across all 5 members, indicating the possibility that these regions may represent key conserved functional motifs. Conclusions We have shown with significant evidence that the 5 members of the class A scavenger receptors form a protein family. We have indicated that these receptors have a common origin which may provide insight into future functional work with these proteins. |
| Related Links | https://bmcecolevol.biomedcentral.com/counter/pdf/10.1186/1471-2148-12-227.pdf |
| Ending Page | 11 |
| Page Count | 11 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 27307182 |
| DOI | 10.1186/1471-2148-12-227 |
| Journal | BMC Ecology and Evolution |
| Issue Number | 1 |
| Volume Number | 12 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2012-11-27 |
| Access Restriction | Open |
| Subject Keyword | Evolutionary Biology Animal Systematics Taxonomy Biogeography Entomology Genetics and Population Dynamics Life Sciences Class A scavenger receptor Innate immunity Scavenger receptor Pattern recognition receptor Scavenger receptor cysteine rich domain Comparative evolution Animal Systematics/Taxonomy/Biogeography |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ecology, Evolution, Behavior and Systematics |
| Journal Impact Factor | 2.3/2023 |
| 5-Year Journal Impact Factor | 2.3/2023 |
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