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| Content Provider | Springer Nature Link |
|---|---|
| Author | Naseripour, Masood Abrishami, Majid Pourmatin, Rama Mosallaei, Navid Falavarjani, Khalil Ghasemi Safarian, Omid Malaekeh Nikouei, Bizhan Sedaghat, Ahad Abrishami, Mojtaba Kanavi, Mozhgan Rezaei |
| Copyright Year | 2016 |
| Abstract | The aim of present study was to evaluate the stability and toxicity of different doses of liposomal melphalan in rabbit eyes and to investigate the pathological and electrophysiological changes after administration of different doses of free form of melphalan. Liposomes containing melphalan were prepared by solvent evaporation method and mean size of these liposomes and encapsulation efficacy of nanoliposomes were determined. In albino rabbits, intravitreal injections of 10, 20, and 40 µg doses of liposomal melphalan and Alkeran$^{®}$ as the commercial product was performed. The rabbits were euthanized at days 2, 7, 14, and 28, and the eyes were enucleated. Vitreous and aqueous samples and electrophysiological recordings were obtained before euthanization. Histological examination was performed after enucleation. Particle size of prepared liposomes was 143.6 ± 3.2 nm. Liposomes have protected melphalan completely from any undesirable release or hydrolysis for 48 h. In a histopathological study, signs of retinal toxicity were found in all doses in the liposomal group at least at one time point during the study. In melphalan injected eyes, histopathological toxicity was found in the 40 µg dose. Extensive variability was found in electrophysiological recordings, and significant waveform changes were found in all injected eyes at least on one occasion during the study. Intraocular administration of liposomal melphalan cannot prolong the drug clearance time of this drug in the vitreous humor. In the 40 µg injected eyes, significant retinal atrophic changes were detected in all eyes throughout the study, and electrophysiological results were consistent with histopathological findings. |
| Starting Page | 575 |
| Ending Page | 582 |
| Page Count | 8 |
| File Format | |
| ISSN | 20935552 |
| Journal | Journal of Pharmaceutical Investigation |
| Volume Number | 46 |
| Issue Number | 6 |
| e-ISSN | 20936214 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2016-08-03 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Nanoliposomes Histopathology Intravitreal injection Melphalan Electrophysiology Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmaceutical Science |
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