NDLI: Intravitreal injection of lipoamino acid-modified connexin43 mimetic peptide enhances neuroprotection after retinal ischemia

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Intravitreal injection of lipoamino acid-modified connexin43 mimetic peptide enhances neuroprotection after retinal ischemia

Content Provider	Springer Nature Link
Author	Chen, Ying Shan Green, Colin R. Teague, Rebecca Perrett, Joshua Danesh Meyer, Helen V. Toth, Istvan Rupenthal, Ilva D.
Copyright Year	2015
Abstract	Optic neuropathy is associated with retinal ganglion cell (RGC) loss leading to optic nerve damage and visual impairment. Recent research has shown that transient block of connexin43 (Cx43) hemichannels by a Cx43 mimetic peptide (MP), Peptide5, delivered systemically or by intravitreal injection after retinal ischemia inhibits uncontrolled hemichannel opening to provide significantly reduced vessel leak and inflammation as well as significantly enhanced RGC survival. We have previously shown, in vitro, that a chemically modified C$_{12}$-C$_{12}$-Cx43 MP has a twofold greater half-life in bovine vitreous (ex vivo) than the native peptide. The present study investigated the ability of intravitreally injected, chemically modified C$_{12}$-C$_{12}$-Cx43 MP to further enhance RGC survival in a rat retinal ischemia-reperfusion model. Intravitreally injected native Cx43 MP or C$_{12}$-C$_{12}$-Cx43 MP both minimized vessel leak, reduced inflammation, and protected RGC after ischemic injury. However, the modified C$_{12}$-C$_{12}$-Cx43 MP, with its prolonged vitreous stability, showed significantly lower levels of Cx43 expression post-injury, with a trend towards a greater reduction in vessel leak and further RGC protection, suggesting that these molecules may be a clinically relevant neuroprotective tool in the treatment of optic neuropathy.
Starting Page	480
Ending Page	488
Page Count	9
File Format	PDF
ISSN	2190393X
Journal	Drug Delivery and Translational Research
Volume Number	5
Issue Number	5
e-ISSN	21903948
Language	English
Publisher	Springer US
Publisher Date	2015-08-04
Publisher Institution	Controlled Release Society
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Connexin43 Mimetic peptide Lipoamino acid Intravitreal injection Retinal ischemia Pharmaceutical Sciences/Technology
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

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