Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | Springer Nature Link |
|---|---|
| Author | Patil, Arun Pandey, Suneel Das, Ujjalkumar |
| Copyright Year | 2014 |
| Abstract | Periodontal disease comprises a group of inflammatory conditions of periodontal tissues with common etiologic agent (bacteria) in the form of dental plaque. The objective of this research was to prepare a water-in-oil type microemulsion comprising metronidazole and equate its potency towards the effective treatment of periodontitis. A pseudo ternary phase diagram for microemulsion investigated using quaternary system containing water/captex 500/ tween 80/acconon CC6. The microemulsion was preferred from the microemulsion area on the phase diagram. Stable water-in-oil type metronidazole microemulsion was prepared successfully using the quaternary system of water/captex 500/ tween 80/acconon CC6 at 4:1 ratio having droplet size in the range of 81 ± 12.91 to 196 ± 10.73 nm, conductivity 50.6 ± 0.8 to 330.7 ± 1.1 μs/cm. In-vitro drug release, in vitro and ex vivo antimicrobial activities by agar well diffusion were investigated. Metronidazole Microemulsion loaded hydrogel formulations (F9 and F10) were found to be optimized for maximum release and antimicrobial activity in terms of zone of inhibition. The in vitro release evidenced that metronidazole microemulsion loaded hydrogel release rate was maximum as compared to other plain metronidazole gels. Stability study proved that microemulsion persisted stable for at least 6 months; with no changes in clarity, characteristic properties, and no sign of crystallization of metronidazole. In ex vivo evaluation, microemulsion based hydrogels were effective against the microbial flora of the human oral cavity suffering from periodontitis. The system was found to be appropriate for application and more effective in reducing the clinical symptoms of periodontitis. |
| Starting Page | 225 |
| Ending Page | 236 |
| Page Count | 12 |
| File Format | |
| ISSN | 20935552 |
| Journal | Journal of Pharmaceutical Investigation |
| Volume Number | 44 |
| Issue Number | 4 |
| e-ISSN | 20936214 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2014-02-22 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Periodontitis Carbopol 940 Metronidazole Hydrogel Microemulsion Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmaceutical Science |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|