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Preparation, characterization and in vitro dissolution of aceclofenac-loaded PVP solid dispersions prepared by spray drying or rotary evaporation method

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Journal of Pharmaceutical Investigation : Volume 43, Issue 1, February 2013

Journal of Pharmaceutical Investigation : Volume 42

Preparation, characterization and in vitro dissolution of aceclofenac-loaded PVP solid dispersions prepared by spray drying or rotary evaporation method

Content Provider	Springer Nature Link
Author	Jang, Ji Eun Khang, Gilson Kim, Seul Ji Jeon, Dea Yeon Lee, Dongwon Lee, Jung Hwan Yoon, Hyeon Kim, Min Jeong
Copyright Year	2013
Abstract	This study was conducted to enhance dissolution rate of aceclofenac (ACF) with extremely low solubility and high permeability (BCS class II) in water using poly vinyl pyrrolidone (PVP) and sodium lauryl sulfate as carriers. Solid dispersions were prepared by spray drying method and rotary evaporation method using different ratios of ACF and polymers. The characterization of solid dispersions was evaluated by scanning electron microscopy, Fourier transformation infrared spectroscopy, differential scanning calorimetry and powder X-ray diffractometer. The dissolution behavior of solid dispersions was compared with pure ACF (API) and Airtal$^{®}$ (Deawoong, Co, Korea) as control groups in simulated phosphate buffer at pH 6.8. The dissolution rate of the drug was affected by nature and amount of polymer used. The prepared solid dispersion of ACF/PVP (1:5) appeared to have the highest dissolution rate. Therefore, solid dispersion techniques of spray drying and rotary evaporation method can be successfully used for the enhancement of the dissolution rate of ACF.
Starting Page	107
Ending Page	113
Page Count	7
File Format	PDF
ISSN	20935552
Journal	Journal of Pharmaceutical Investigation
Volume Number	43
Issue Number	2
e-ISSN	20936214
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-03-07
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Rotary evaporation Amorphous Spray drying Solid dispersion Aceclofenac Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

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