NDLI: Design and evaluation of esmolol hydrochloride ocular inserts with special reference to glaucoma treatment

Please wait, while we are loading the content...

Preparation, characterization and in vitro dissolution of aceclofenac-loaded PVP solid dispersions prepared by spray drying or rotary evaporation method

Optimization for glimepiride dissolution enhancement utilizing different carriers and techniques

Mathematical optimization and characterisation of pharmaceutically developed novel buccoadhesive wafers for rapid bioactive delivery of Loratadine

Proliferation and chondrogenic differentiation of human adipose-derived mesenchymal stem cells in sodium alginate beads with or without hyaluronic acid

Bioequivalence of Torad tablet 5 mg to Torem tablet 5 mg (torasemide 5 mg)

Journal of Pharmaceutical Investigation : Volume 43, Issue 1, February 2013

Journal of Pharmaceutical Investigation : Volume 42

Design and evaluation of esmolol hydrochloride ocular inserts with special reference to glaucoma treatment

Content Provider	Springer Nature Link
Author	Paliwal, Sarvesh Dave, Vivek Sharma, Swapnil
Copyright Year	2013
Abstract	In developing a drug delivery strategy, issues of absorption, distribution, metabolism, and elimination must be considered. The eye presents unique opportunities and challenges when it comes to the delivery of pharmaceuticals. While absorption by this route is bungling, there are few side effects with conventional ocular dosage forms. Hence, ocular inserts were prepared with prolonged release of drug and minimum swelling within cul-de-sac using esmolol HCl drug the work focuses on treatment of glaucoma by formulating ocular inserts. By using different polymeric combination of esmolol HCl using hydroxypropyl methyl cellulose (HPMC 3–5 %), chitosan (3–5 %), polyvinyl alcohol (PVA 3–5 %), methyl cellulose (3–5 %) as polymer by solvent casting technique with objective of increasing contact time, achieving controlled release, reduction on frequency of administration and greater therapeutic efficiency. The prepared ocular insert were then evaluated for physical appearances tensile strength, % elongation at break, stress, weight variation, uniformity of thickness, % moisture absorption, surface pH, folding endurance, Fourier transform infrared spectroscopy, in-vitro transcorneal permeation studies etc. It is evident from these study that formed polymeric ocular insert have appreciable strength and safety. Physicochemical characterization and in vitro transcorneal permeation studies revels that, the prepared ocular insert formulation F2 and F8 containing HPMC and PVA had release their drug content, 98.54 and 97.24 respectively over a extended period of 24 h. Hence these formulation selected as best optimized formulation.
Starting Page	89
Ending Page	99
Page Count	11
File Format	PDF
ISSN	20935552
Journal	Journal of Pharmaceutical Investigation
Volume Number	43
Issue Number	2
e-ISSN	20936214
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-03-06
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	MC Esmolol hydrochloride PVA Chitosan Biomedicine general HPMC
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Formulation optimization of PVA/HPMC cryogel of Diltiazem HCl using 3-level factorial design and evaluation for ex vivo permeation

Sustained release ocular inserts of brimonidine tartrate for better treatment in open-angle glaucoma

Design and evaluation of moxifloxacin hydrochloride ocular inserts

Dissolution properties of control released solid dispersion of carvedilol with HPMC and Eudragit RS

In vitro microbiological evaluation of polyvinyl alcohol-based ocular inserts of Ciprofloxacin hydrochloride

Development and evaluation of film coated aceclofenac and chlorzoxazone tablet with enhanced dissolution rate

Evaluation of mucoadhesive nanoparticle based nasal vaccine

Development and statistical optimization of chitosan and eudragit based gastroretentive controlled release multiparticulate system for bioavailability enhancement of metformin HCl

Chitosan reinforced alginate controlled release beads of losartan potassium: design, formulation and in vitro evaluation

Design and evaluation of esmolol hydrochloride ocular inserts with special reference to glaucoma treatment

Similar Documents

Formulation optimization of PVA/HPMC cryogel of Diltiazem HCl using 3-level factorial design and evaluation for ex vivo permeation

Sustained release ocular inserts of brimonidine tartrate for better treatment in open-angle glaucoma

Design and evaluation of moxifloxacin hydrochloride ocular inserts

Dissolution properties of control released solid dispersion of carvedilol with HPMC and Eudragit RS

In vitro microbiological evaluation of polyvinyl alcohol-based ocular inserts of Ciprofloxacin hydrochloride

Development and evaluation of film coated aceclofenac and chlorzoxazone tablet with enhanced dissolution rate

Evaluation of mucoadhesive nanoparticle based nasal vaccine

Development and statistical optimization of chitosan and eudragit based gastroretentive controlled release multiparticulate system for bioavailability enhancement of metformin HCl

Chitosan reinforced alginate controlled release beads of losartan potassium: design, formulation and in vitro evaluation

Design and evaluation of esmolol hydrochloride ocular inserts with special reference to glaucoma treatment