NDLI: Effect of a monoclonal antibody against human relaxin-2 on cancer cell growth inhibition

Content Provider	Springer Nature Link
Author	Park, Byoung Kwon Kwon, Hyung Joo Lee, Younghee Cho, Sooyoung Lee, Su In Lee, Young Seek
Copyright Year	2016
Abstract	Relaxin-2 has gained much attention because of its importance in cancer cell proliferation, invasion, and angiogenesis. However, the potential of relaxin-2 as a target for immunotherapy has never been directly validated before. In the present study, we produced a human relaxin-2-specific antibody by immunizing mice using a specific liposome complex containing relaxin-2 epitope peptide and CpG-DNA. We isolated a hybridoma clone, 1B11F12, producing the anti-relaxin-2 monoclonal antibody. We confirmed with immunoprecipitation analysis that the antibody specifically recognizes native human relaxin-2. Treatment with the antibody suppressed the growth of some cancer cell lines. Therefore, we suggest that relaxin-2 could be a reasonable target of cancer therapeutics, and the monoclonal antibody could be used to treat cancer in humans.
Starting Page	739
Ending Page	746
Page Count	8
File Format	PDF
ISSN	24680834
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	59
Issue Number	5
e-ISSN	24680842
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-08-19
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Applied Microbiology Biological Techniques Monoclonal antibody Bioorganic Chemistry Cancer Relaxin-2
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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