NDLI: Quercetin and quercetin-3-β-d-glucoside improve cognitive and memory function in Alzheimer’s disease mouse

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Quercetin and quercetin-3-β-d-glucoside improve cognitive and memory function in Alzheimer’s disease mouse

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Journal of the Korean Society for Applied Biological Chemistry : Volume 59, Issue 3, June 2016

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Quercetin and quercetin-3-β-d-glucoside improve cognitive and memory function in Alzheimer’s disease mouse

Content Provider	Springer Nature Link
Author	Lee, Jaemin Lee, Sanghyun Cho, Eun Ju Kim, Ji Hyun
Copyright Year	2016
Abstract	We investigated the protective activities of quercetin (Q) and quercetin-3-β-d-glucoside (Q3G) under Aβ$_{25–35}$-injected Alzheimer’s disease (AD) model mice. To induce an AD-like disease in an in vivo model, mice were injected with Aβ$_{25–35}$ via the intracerebroventricular route. Q and Q3G were administered orally for 14 days at 30 mg/kg/day. Learning and memory functions were evaluated using behavioral experiments that comprise tests like T-maze, Morris water maze, and novel object recognition. The administration of Q and Q3G improved memory and cognitive function, compared with Aβ$_{25–35}$-injected control mice in the T-maze and object recognition test. Q and Q3G administration decreased time in order to get to the platform during the Morris water maze test. The group administered Q experienced higher protective effects from long-term spatial memory and learning ability impairments than the group administered Q3G. Furthermore, lipid peroxidation and NO formation in the brain were significantly elevated in Aβ$_{25–35}$-injected control mice, and this was inhibited by Q and Q3G. These results demonstrated that Q and Q3G improved Aβ$_{25–35}$-induced memory deficits and cognitive impairment and promoted protection in the brain against oxidative stress.
Starting Page	721
Ending Page	728
Page Count	8
File Format	PDF
ISSN	24680834
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	59
Issue Number	5
e-ISSN	24680842
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-07-13
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Oxidative stress Amyloid beta Alzheimer’s disease Quercetin Applied Microbiology Biological Techniques Quercetin-3-β-d-glucoside Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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