NDLI: Growth inhibiting activity of quinaldic acid isolated from Ephedra pachyclada against intestinal bacteria

Content Provider	Springer Nature Link
Author	Lee, Hoi Seon Lee, Chi Hoon
Copyright Year	2003
Abstract	The growth inhibiting activity of materials derived from the stems of Ephedra pachyclada against intestinal bacteria was examined. Purification of the active constituent from E. pachyclada stems was conducted by silica gel chromatography and HPLC. The structure of the active component was identified as quinaldic acid (C$_{10}$H$_{7}$NO$_{2}$, 173, quinoline-2-caboxylic acid) using various spectroscopic analyses including EI-MS, 1H-NMR, and $^{13}$C-NMR. The growth inhibiting activity varied according to the chemical, dose, and bacterial strain tested. Quinaldic acid showed a strong (+++) inhibition at 1.0 mg/disc against Clostridium difficile and Clostridium perfringens, and moderately inhibited the growth of C. Difficile and C. Perfringens at 0.5 and 0.1 mg/disc, respectively, but had no effect on the growth of Bifidobacterium bifidum, Lactobacillus acidophilus, and Lactobacillus casei. These results indicate that quinaldic acid should be considered as a possible antimicrobial agent for the treatment of diseases associated with intestinal bacteria.
Starting Page	331
Ending Page	335
Page Count	5
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	52
Issue Number	4
e-ISSN	2234344X
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	intestinal bacteria quinaldic acid Ephedra pachyclada growth inhibiting Applied Microbiology Biological Techniques Clostridium perfringens Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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