NDLI: Inhibition of xanthine oxidase by phenolic phytochemicals from Broussonetia papyrifera

Content Provider	Springer Nature Link
Author	Lee, Ji Hye Jin, Young Min Park, Ki Hun Kang, Jae Eun Ryu, Hyung Won
Copyright Year	2012
Abstract	The roots of Broussonetia papyrifera were extracted into four different polar solvents: chloroform, 50% ethanol in water, ethanol, and water. The ethanol extract showed the most potent inhibition (72.3% at 20 g/mL) against xanthine oxidase (XOD). Chromatography of EE yielded nine phenolic phytochemicals, which were confirmed as broussochalcone A (1), broussochalcone B (2), 3,4-dihydroxyisolonchocarpin (3), 4-hydroxyisolonchocarpin (4), 3-′(3-methylbut-2-enyl)-3′,4′,7-trihydroxyflavane (5), kazinol A (6), kazinol B (7), kazinol E (8), and broussoflavan A (9). All isolated compounds (19) possessed potent antioxidant activities against 2,2-diphenyl-l-picrylhydrazyl and 2,2′-azino-bis-ethylbenzthiazoline-6-sulfonic acid (ABTS) radicals with IC$_{50}$ values ranging from 5.8 to 252.8M. Although most compounds exhibited potent inhibition with IC$_{50}$ values ranging 0.6–164 M against XOD, compounds 1 and 3 were found to be the principal contributors to the XOD inhibition in ethanol extract. The analysis of K $_{I}$ and K $_{IS}$ values proved that the two most promising compounds (1 and 3), present at high concentrations in the root barks as analyzed by using high-performance liquid chromatography analysis, were reversible mixed type I inhibitors.
Starting Page	587
Ending Page	594
Page Count	8
File Format	PDF
ISSN	17382203
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume Number	55
Issue Number	5
e-ISSN	2234344X
Language	English
Publisher	The Korean Society for Applied Biological Chemistry
Publisher Date	2012-10-31
Publisher Place	Seoul
Access Restriction	Subscribed
Subject Keyword	Broussonetia papyrifera antioxidant effect Applied Microbiology Biological Techniques phenolic phytochemicals xanthine oxidase Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry, Genetics and Molecular Biology

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